STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
metH4Methionine synthase. (791 aa)    
Predicted Functional Partners:
KNF08979.1
Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase.
 
 
0.999
metF
5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.
 
 
 0.998
metH2
Vitamin B12-dependent methionine synthase MetH.
 
 
 0.971
metH
Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
 
 
0.958
cysD3
O-acetylhomoserine (thiol)-lyase CysD.
  
 
 0.957
hom
Homoserine dehydrogenase Hom.
  
 
 0.931
gcvT
Aminomethyltransferase GcvT; The glycine cleavage system catalyzes the degradation of glycine.
  
 
 0.912
fhs
Formate--tetrahydrofolate ligase Fhs.
  
 
 0.907
luxS
S-ribosylhomocysteine lyase LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family.
    
 0.905
lysC2
Aspartate kinase LysC; Belongs to the aspartokinase family.
  
 
 0.904
Your Current Organism:
Gottschalkia purinilytica
NCBI taxonomy Id: 1503
Other names: ATCC 33906, Clostridium purinilyticum, Clostridium purinolyticum, G. purinilytica, strain WA-1
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.