| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| KNF08979.1 | KNF09604.1 | CLPU_4c00250 | CLPU_2c00550 | Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase. | Nucleoside-diphosphate-sugar epimerase. | 0.453 |
| KNF08979.1 | hisIE | CLPU_4c00250 | CLPU_1c03300 | Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase. | Histidine biosynthesis bifunctional protein HisIE; In the N-terminal section; belongs to the PRA-CH family. | 0.579 |
| KNF08979.1 | metF | CLPU_4c00250 | CLPU_18c00040 | Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase. | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.673 |
| KNF08979.1 | metH | CLPU_4c00250 | CLPU_21c00330 | Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.994 |
| KNF08979.1 | metH2 | CLPU_4c00250 | CLPU_18c00050 | Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase. | Vitamin B12-dependent methionine synthase MetH. | 0.969 |
| KNF08979.1 | metH4 | CLPU_4c00250 | CLPU_18c00060 | Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase. | Methionine synthase. | 0.994 |
| KNF08979.1 | metK | CLPU_4c00250 | CLPU_2c01320 | Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase. | S-adenosylmethionine synthase MetK; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.935 |
| KNF09604.1 | KNF08979.1 | CLPU_2c00550 | CLPU_4c00250 | Nucleoside-diphosphate-sugar epimerase. | Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase. | 0.453 |
| KNF09604.1 | hisIE | CLPU_2c00550 | CLPU_1c03300 | Nucleoside-diphosphate-sugar epimerase. | Histidine biosynthesis bifunctional protein HisIE; In the N-terminal section; belongs to the PRA-CH family. | 0.590 |
| KNF09604.1 | metK | CLPU_2c00550 | CLPU_2c01320 | Nucleoside-diphosphate-sugar epimerase. | S-adenosylmethionine synthase MetK; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.825 |
| birA | metK | CLPU_12c00960 | CLPU_2c01320 | Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | S-adenosylmethionine synthase MetK; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.709 |
| groL | metK | CLPU_2c00360 | CLPU_2c01320 | 60 kDa chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | S-adenosylmethionine synthase MetK; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.740 |
| hisIE | KNF08979.1 | CLPU_1c03300 | CLPU_4c00250 | Histidine biosynthesis bifunctional protein HisIE; In the N-terminal section; belongs to the PRA-CH family. | Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase. | 0.579 |
| hisIE | KNF09604.1 | CLPU_1c03300 | CLPU_2c00550 | Histidine biosynthesis bifunctional protein HisIE; In the N-terminal section; belongs to the PRA-CH family. | Nucleoside-diphosphate-sugar epimerase. | 0.590 |
| hisIE | metH | CLPU_1c03300 | CLPU_21c00330 | Histidine biosynthesis bifunctional protein HisIE; In the N-terminal section; belongs to the PRA-CH family. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.437 |
| hisIE | metH4 | CLPU_1c03300 | CLPU_18c00060 | Histidine biosynthesis bifunctional protein HisIE; In the N-terminal section; belongs to the PRA-CH family. | Methionine synthase. | 0.437 |
| hisIE | metK | CLPU_1c03300 | CLPU_2c01320 | Histidine biosynthesis bifunctional protein HisIE; In the N-terminal section; belongs to the PRA-CH family. | S-adenosylmethionine synthase MetK; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.680 |
| metF | KNF08979.1 | CLPU_18c00040 | CLPU_4c00250 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase. | 0.673 |
| metF | metH | CLPU_18c00040 | CLPU_21c00330 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.992 |
| metF | metH2 | CLPU_18c00040 | CLPU_18c00050 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Vitamin B12-dependent methionine synthase MetH. | 0.976 |
