metK-2 protein (Gottschalkia purinilytica) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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Knowledge-based Evidence

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Assay-based Predictions

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co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

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Your Current Organism:

Gottschalkia purinilytica

NCBI taxonomy Id: 1503
Other names: ATCC 33906, Clostridium purinilyticum, Clostridium purinolyticum, G. purinilytica, strain WA-1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KNF08427.1	KNF08429.1	CLPU_7c00550	CLPU_7c00570	Phage terminase, small subunit.	DNA modification methylase; Belongs to the N(4)/N(6)-methyltransferase family.	0.956
KNF08427.1	KNF08430.1	CLPU_7c00550	CLPU_7c00580	Phage terminase, small subunit.	Site-specific DNA methylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.878
KNF08427.1	metK-2	CLPU_7c00550	CLPU_7c00560	Phage terminase, small subunit.	S-adenosylmethionine synthase MetK; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.	0.737
KNF08429.1	KNF08427.1	CLPU_7c00570	CLPU_7c00550	DNA modification methylase; Belongs to the N(4)/N(6)-methyltransferase family.	Phage terminase, small subunit.	0.956
KNF08429.1	KNF08430.1	CLPU_7c00570	CLPU_7c00580	DNA modification methylase; Belongs to the N(4)/N(6)-methyltransferase family.	Site-specific DNA methylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.878
KNF08429.1	birA	CLPU_7c00570	CLPU_12c00960	DNA modification methylase; Belongs to the N(4)/N(6)-methyltransferase family.	Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.	0.400
KNF08429.1	metK-2	CLPU_7c00570	CLPU_7c00560	DNA modification methylase; Belongs to the N(4)/N(6)-methyltransferase family.	S-adenosylmethionine synthase MetK; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.	0.833
KNF08430.1	KNF08427.1	CLPU_7c00580	CLPU_7c00550	Site-specific DNA methylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Phage terminase, small subunit.	0.878
KNF08430.1	KNF08429.1	CLPU_7c00580	CLPU_7c00570	Site-specific DNA methylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	DNA modification methylase; Belongs to the N(4)/N(6)-methyltransferase family.	0.878
KNF08430.1	metK-2	CLPU_7c00580	CLPU_7c00560	Site-specific DNA methylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	S-adenosylmethionine synthase MetK; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.	0.884
KNF08979.1	KNF09604.1	CLPU_4c00250	CLPU_2c00550	Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase.	Nucleoside-diphosphate-sugar epimerase.	0.453
KNF08979.1	metH	CLPU_4c00250	CLPU_21c00330	Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase.	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.994
KNF08979.1	metH4	CLPU_4c00250	CLPU_18c00060	Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase.	Methionine synthase.	0.994
KNF08979.1	metK-2	CLPU_4c00250	CLPU_7c00560	Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase.	S-adenosylmethionine synthase MetK; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.	0.935
KNF09604.1	KNF08979.1	CLPU_2c00550	CLPU_4c00250	Nucleoside-diphosphate-sugar epimerase.	Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase.	0.453
KNF09604.1	metK-2	CLPU_2c00550	CLPU_7c00560	Nucleoside-diphosphate-sugar epimerase.	S-adenosylmethionine synthase MetK; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.	0.825
birA	KNF08429.1	CLPU_12c00960	CLPU_7c00570	Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.	DNA modification methylase; Belongs to the N(4)/N(6)-methyltransferase family.	0.400
birA	metK-2	CLPU_12c00960	CLPU_7c00560	Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.	S-adenosylmethionine synthase MetK; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.	0.709
groL	metK-2	CLPU_2c00360	CLPU_7c00560	60 kDa chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.	S-adenosylmethionine synthase MetK; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.	0.740
metH	KNF08979.1	CLPU_21c00330	CLPU_4c00250	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase.	0.994