| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| birA | guaA | CLPU_12c00960 | CLPU_2c00320 | Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.684 |
| birA | ribBA | CLPU_12c00960 | CLPU_8c00280 | Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | Riboflavin biosynthesis protein RibBA; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.794 |
| birA | tadA | CLPU_12c00960 | CLPU_7c01410 | Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | tRNA-specific adenosine deaminase TadA. | 0.865 |
| birA | tilS | CLPU_12c00960 | CLPU_12c00930 | Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | tRNA(Ile)-lysidine synthase TilS; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. | 0.526 |
| guaA | birA | CLPU_2c00320 | CLPU_12c00960 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | 0.684 |
| guaA | punA | CLPU_2c00320 | CLPU_17c00500 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Purine nucleoside phosphorylase 1; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.726 |
| guaA | ribBA | CLPU_2c00320 | CLPU_8c00280 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Riboflavin biosynthesis protein RibBA; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.853 |
| guaA | tadA | CLPU_2c00320 | CLPU_7c01410 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | tRNA-specific adenosine deaminase TadA. | 0.634 |
| guaA | tilS | CLPU_2c00320 | CLPU_12c00930 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | tRNA(Ile)-lysidine synthase TilS; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. | 0.866 |
| guaA | xpt | CLPU_2c00320 | CLPU_1c01720 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Xanthine phosphoribosyltransferase Xpt; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.942 |
| hisIE | ribBA | CLPU_1c03300 | CLPU_8c00280 | Histidine biosynthesis bifunctional protein HisIE; In the N-terminal section; belongs to the PRA-CH family. | Riboflavin biosynthesis protein RibBA; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.733 |
| hisIE | tadA | CLPU_1c03300 | CLPU_7c01410 | Histidine biosynthesis bifunctional protein HisIE; In the N-terminal section; belongs to the PRA-CH family. | tRNA-specific adenosine deaminase TadA. | 0.891 |
| hisIE | xpt | CLPU_1c03300 | CLPU_1c01720 | Histidine biosynthesis bifunctional protein HisIE; In the N-terminal section; belongs to the PRA-CH family. | Xanthine phosphoribosyltransferase Xpt; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.782 |
| ndhF | punA | CLPU_25c00160 | CLPU_17c00500 | Nicotinate dehydrogenase FAD-subunit. | Purine nucleoside phosphorylase 1; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.743 |
| ndhF | tadA | CLPU_25c00160 | CLPU_7c01410 | Nicotinate dehydrogenase FAD-subunit. | tRNA-specific adenosine deaminase TadA. | 0.790 |
| ndhF | xpt | CLPU_25c00160 | CLPU_1c01720 | Nicotinate dehydrogenase FAD-subunit. | Xanthine phosphoribosyltransferase Xpt; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.745 |
| ndhF | ylmD | CLPU_25c00160 | CLPU_1c00740 | Nicotinate dehydrogenase FAD-subunit. | Laccase domain-containing protein YlmD; Belongs to the multicopper oxidase YfiH/RL5 family. | 0.743 |
| pbuX | tadA | CLPU_7c01420 | CLPU_7c01410 | Xanthine permease. | tRNA-specific adenosine deaminase TadA. | 0.570 |
| punA | guaA | CLPU_17c00500 | CLPU_2c00320 | Purine nucleoside phosphorylase 1; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.726 |
| punA | ndhF | CLPU_17c00500 | CLPU_25c00160 | Purine nucleoside phosphorylase 1; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | Nicotinate dehydrogenase FAD-subunit. | 0.743 |