ku protein (Bacillus caseinilyticus) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

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ku

DNA end-binding protein Ku; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family. (282 aa)

Predicted Functional Partners:

SDZ53986.1

0.962

SDZ53916.1

0.866

SDZ53865.1

0.542

SDZ19681.1

0.448

SDZ24355.1

0.447

Your Current Organism:

Bacillus caseinilyticus

NCBI taxonomy Id: 1503961
Other names: B. caseinilyticus, Bacillus caseinilyticus Reddy et al. 2015, Bacillus sp. SP, JCM 30246, MCC 2612, strain SP

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SDZ19681.1	SDZ53986.1	SAMN05421736_107155	SAMN05421736_11672	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family.	Bifunctional non-homologous end joining protein LigD.	0.405
SDZ19681.1	ku	SAMN05421736_107155	SAMN05421736_11663	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family.	DNA end-binding protein Ku; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.	0.448
SDZ24355.1	ku	SAMN05421736_10879	SAMN05421736_11663	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family.	DNA end-binding protein Ku; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.	0.447
SDZ53865.1	ku	SAMN05421736_11662	SAMN05421736_11663	Hypothetical protein.	DNA end-binding protein Ku; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.	0.542
SDZ53916.1	SDZ53986.1	SAMN05421736_11666	SAMN05421736_11672	Bifunctional non-homologous end joining protein LigD.	Bifunctional non-homologous end joining protein LigD.	0.990
SDZ53916.1	ku	SAMN05421736_11666	SAMN05421736_11663	Bifunctional non-homologous end joining protein LigD.	DNA end-binding protein Ku; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.	0.866
SDZ53986.1	SDZ19681.1	SAMN05421736_11672	SAMN05421736_107155	Bifunctional non-homologous end joining protein LigD.	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family.	0.405
SDZ53986.1	SDZ53916.1	SAMN05421736_11672	SAMN05421736_11666	Bifunctional non-homologous end joining protein LigD.	Bifunctional non-homologous end joining protein LigD.	0.990
SDZ53986.1	ku	SAMN05421736_11672	SAMN05421736_11663	Bifunctional non-homologous end joining protein LigD.	DNA end-binding protein Ku; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.	0.962
ku	SDZ19681.1	SAMN05421736_11663	SAMN05421736_107155	DNA end-binding protein Ku; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family.	0.448
ku	SDZ24355.1	SAMN05421736_11663	SAMN05421736_10879	DNA end-binding protein Ku; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family.	0.447
ku	SDZ53865.1	SAMN05421736_11663	SAMN05421736_11662	DNA end-binding protein Ku; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.	Hypothetical protein.	0.542
ku	SDZ53916.1	SAMN05421736_11663	SAMN05421736_11666	DNA end-binding protein Ku; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.	Bifunctional non-homologous end joining protein LigD.	0.866
ku	SDZ53986.1	SAMN05421736_11663	SAMN05421736_11672	DNA end-binding protein Ku; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.	Bifunctional non-homologous end joining protein LigD.	0.962

Network Stats

number of nodes:

11

number of edges:

44

average node degree:

8

avg. local clustering coefficient:

0.83

expected number of edges:

20

PPI enrichment p-value:

1.57e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000036

Acyl carrier activity

4 of 4

2.46

2.89

3.24e-06

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1546

Mixed, incl. Phosphopantetheine, and AMP-binding enzyme

8 of 12

2.29

6.05

5.29e-14

CL:1543

Fatty acid biosynthesis, and Phosphopantetheine

9 of 30

1.94

4.94

5.29e-14

CL:1549

AMP-binding enzyme, and Acyl carrier activity

5 of 6

2.38

4.08

7.70e-09

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00473

D-Alanine metabolism

2 of 4

2.16

0.94

0.0180

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005737

Cytoplasm

10 of 745

0.59

0.47

0.0011

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0596

Phosphopantetheine

5 of 5

2.46

4.16

7.36e-09

KW-0275

Fatty acid biosynthesis

2 of 6

1.99

0.83

0.0266

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00550

Phosphopantetheine attachment site

5 of 5

2.46

3.96

1.96e-08

PF00501

AMP-binding enzyme

3 of 6

2.16

1.68

0.00060

PF00668

Condensation domain

2 of 2

2.46

1.09

0.0102

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036736

ACP-like superfamily

5 of 5

2.46

3.75

5.29e-08

IPR009081

Phosphopantetheine binding ACP domain

5 of 5

2.46

3.75

5.29e-08

IPR045851

AMP-binding enzyme, C-terminal domain superfamily

3 of 6

2.16

1.55

0.0011

IPR000873

AMP-dependent synthetase/ligase domain

3 of 6

2.16

1.55

0.0011

IPR042099

ANL, N-terminal domain

3 of 7

2.1

1.53

0.0011

(more ...)

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