B0A48_15623 protein (Rachicladosporium antarcticum)

Nodes:

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second shell of interactors

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

Your Input:

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[Homology]

Score

B0A48_15623

Uncharacterized protein. (1168 aa)

Predicted Functional Partners:

B0A48_02662

0.882

B0A48_07555

0.854

B0A48_02726

0.835

B0A48_05329

0.795

B0A48_09722

0.778

B0A48_04996

0.778

B0A48_06362

0.773

B0A48_02400

0.773

B0A48_08193

0.765

B0A48_03126

0.765

Your Current Organism:

Rachicladosporium antarcticum

NCBI taxonomy Id: 1507870
Other names: CCFEE 5527, R. antarcticum, Rachicladosporium antarcticum Onofri & Egidi, 2014

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B0A48_02400	B0A48_03126	A0A1V8TNI8	A0A1V8TME5	RuvB-like helicase; DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.	Uncharacterized protein; Belongs to the actin family.	0.987
B0A48_02400	B0A48_08193	A0A1V8TNI8	A0A1V8T181	RuvB-like helicase; DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.	Uncharacterized protein; Belongs to the actin family.	0.987
B0A48_02400	B0A48_15623	A0A1V8TNI8	A0A1V8SGU3	RuvB-like helicase; DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.	Uncharacterized protein.	0.773
B0A48_02662	B0A48_02726	A0A1V8T0B2	A0A1V8T105	Ubiquitin-like domain-containing protein.	Ubiquitin-conjugating enzyme variant MMS2.	0.865
B0A48_02662	B0A48_03126	A0A1V8T0B2	A0A1V8TME5	Ubiquitin-like domain-containing protein.	Uncharacterized protein; Belongs to the actin family.	0.467
B0A48_02662	B0A48_07555	A0A1V8T0B2	A0A1V8STB4	Ubiquitin-like domain-containing protein.	Ubiquitin-conjugating enzyme E2 36; Belongs to the ubiquitin-conjugating enzyme family.	0.899
B0A48_02662	B0A48_08193	A0A1V8T0B2	A0A1V8T181	Ubiquitin-like domain-containing protein.	Uncharacterized protein; Belongs to the actin family.	0.467
B0A48_02662	B0A48_15623	A0A1V8T0B2	A0A1V8SGU3	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.882
B0A48_02726	B0A48_02662	A0A1V8T105	A0A1V8T0B2	Ubiquitin-conjugating enzyme variant MMS2.	Ubiquitin-like domain-containing protein.	0.865
B0A48_02726	B0A48_04996	A0A1V8T105	A0A1V8TE96	Ubiquitin-conjugating enzyme variant MMS2.	Uncharacterized protein.	0.847
B0A48_02726	B0A48_05329	A0A1V8T105	A0A1V8TIF5	Ubiquitin-conjugating enzyme variant MMS2.	Uncharacterized protein.	0.865
B0A48_02726	B0A48_07555	A0A1V8T105	A0A1V8STB4	Ubiquitin-conjugating enzyme variant MMS2.	Ubiquitin-conjugating enzyme E2 36; Belongs to the ubiquitin-conjugating enzyme family.	0.999
B0A48_02726	B0A48_09722	A0A1V8T105	A0A1V8T2R5	Ubiquitin-conjugating enzyme variant MMS2.	Uncharacterized protein.	0.847
B0A48_02726	B0A48_15623	A0A1V8T105	A0A1V8SGU3	Ubiquitin-conjugating enzyme variant MMS2.	Uncharacterized protein.	0.835
B0A48_03126	B0A48_02400	A0A1V8TME5	A0A1V8TNI8	Uncharacterized protein; Belongs to the actin family.	RuvB-like helicase; DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.	0.987
B0A48_03126	B0A48_02662	A0A1V8TME5	A0A1V8T0B2	Uncharacterized protein; Belongs to the actin family.	Ubiquitin-like domain-containing protein.	0.467
B0A48_03126	B0A48_05329	A0A1V8TME5	A0A1V8TIF5	Uncharacterized protein; Belongs to the actin family.	Uncharacterized protein.	0.467
B0A48_03126	B0A48_06362	A0A1V8TME5	A0A1V8TBD6	Uncharacterized protein; Belongs to the actin family.	RuvB-like helicase; DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.	0.987
B0A48_03126	B0A48_15623	A0A1V8TME5	A0A1V8SGU3	Uncharacterized protein; Belongs to the actin family.	Uncharacterized protein.	0.765
B0A48_04996	B0A48_02726	A0A1V8TE96	A0A1V8T105	Uncharacterized protein.	Ubiquitin-conjugating enzyme variant MMS2.	0.847

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

28

PPI enrichment p-value:

1.83e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0032784

Regulation of DNA-templated transcription, elongation

7 of 21

2.43

5.76

1.57e-12

GO:0032786

Positive regulation of DNA-templated transcription, elongation

6 of 19

2.41

4.81

2.09e-10

GO:0034243

Regulation of transcription elongation from RNA polymerase II promoter

3 of 14

2.24

2.06

0.00011

GO:0031401

Positive regulation of protein modification process

3 of 31

1.89

1.56

0.00070

GO:0010604

Positive regulation of macromolecule metabolic process

7 of 292

1.29

1.48

1.57e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016538

Cyclin-dependent protein serine/threonine kinase regulator activity

3 of 16

2.18

1.41

0.0021

GO:0061575

Cyclin-dependent protein serine/threonine kinase activator activity

2 of 3

2.73

1.08

0.0108

GO:0008353

RNA polymerase II CTD heptapeptide repeat kinase activity

2 of 5

2.51

1.08

0.0108

GO:0004693

Cyclin-dependent protein serine/threonine kinase activity

2 of 12

2.13

0.84

0.0278

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019908

Nuclear cyclin-dependent protein kinase holoenzyme complex

5 of 5

2.91

5.43

7.41e-11

GO:0000307

Cyclin-dependent protein kinase holoenzyme complex

6 of 18

2.43

5.03

7.41e-11

GO:0008023

Transcription elongation factor complex

6 of 19

2.41

5.0

7.41e-11

GO:0032806

Carboxy-terminal domain protein kinase complex

5 of 14

2.46

4.57

9.51e-10

GO:0008024

cyclin/CDK positive transcription elongation factor complex

4 of 4

2.91

4.44

6.10e-09

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1689

RNA Polymerase II Pre-transcription Events, and RNA polymerase core enzyme binding

10 of 80

2.0

5.86

1.17e-16

CL:1833

cyclin/CDK positive transcription elongation factor complex, and Glucose receptor Git3, N-terminal

5 of 7

2.76

5.08

2.52e-10

CL:1768

RNA Polymerase II Transcription Elongation

4 of 28

2.06

2.44

1.03e-05

CL:1690

RNA polymerase II, holoenzyme, and RNA polymerase core enzyme binding

5 of 71

1.76

2.27

4.73e-06

CL:1772

RNA polymerase II, core complex

3 of 11

2.34

2.13

9.09e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-6796648

TP53 Regulates Transcription of DNA Repair Genes

9 of 40

2.26

6.92

1.08e-16

MAP-674695

RNA Polymerase II Pre-transcription Events

9 of 67

2.04

5.61

3.71e-15

MAP-75955

RNA Polymerase II Transcription Elongation

6 of 43

2.05

3.93

1.41e-09

MAP-6807505

RNA polymerase II transcribes snRNA genes

7 of 75

1.88

3.75

3.19e-10

MAP-113418

Formation of the Early Elongation Complex

5 of 32

2.1

3.43

4.92e-08

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0008024

cyclin/CDK positive transcription elongation factor complex

5 of 6

2.83

5.24

1.46e-10

GOCC:0032806

Carboxy-terminal domain protein kinase complex

6 of 18

2.43

5.01

8.54e-11

GOCC:0008023

Transcription elongation factor complex

6 of 22

2.34

4.83

1.19e-10

GOCC:0061695

Transferase complex, transferring phosphorus-containing groups

8 of 150

1.63

3.08

3.11e-10

GOCC:0005654

Nucleoplasm

7 of 236

1.38

1.93

2.98e-07

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0195

Cyclin

2 of 7

2.36

1.05

0.0116

KW-0804

Transcription

3 of 109

1.35

0.67

0.0346

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00385

Domain present in cyclins, TFIIB and Retinoblastoma

2 of 10

2.21

0.84

0.0282

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