B0A48_14257 protein (Rachicladosporium antarcticum)

Nodes:

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

B0A48_14257

Uncharacterized protein. (464 aa)

Predicted Functional Partners:

B0A48_11954

0.893

B0A48_09066

0.893

B0A48_01126

0.893

B0A48_00319

0.893

B0A48_11765

0.830

B0A48_07627

0.830

B0A48_16238

0.828

B0A48_01908

0.828

B0A48_06548

0.817

B0A48_02216

0.817

Your Current Organism:

Rachicladosporium antarcticum

NCBI taxonomy Id: 1507870
Other names: CCFEE 5527, R. antarcticum, Rachicladosporium antarcticum Onofri & Egidi, 2014

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B0A48_00319	B0A48_01126	A0A1V8TUB6	A0A1V8TSC1	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.953
B0A48_00319	B0A48_01908	A0A1V8TUB6	A0A1V8TQM2	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	ETF domain-containing protein.	0.535
B0A48_00319	B0A48_02216	A0A1V8TUB6	A0A1V8TNG7	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	Uncharacterized protein.	0.945
B0A48_00319	B0A48_06548	A0A1V8TUB6	A0A1V8TBQ8	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	Uncharacterized protein.	0.944
B0A48_00319	B0A48_07627	A0A1V8TUB6	A0A1V8T715	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	ETF domain-containing protein.	0.659
B0A48_00319	B0A48_09066	A0A1V8TUB6	A0A1V8T249	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.953
B0A48_00319	B0A48_11765	A0A1V8TUB6	A0A1V8ST76	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	ETF domain-containing protein.	0.659
B0A48_00319	B0A48_11954	A0A1V8TUB6	A0A1V8STA5	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.953
B0A48_00319	B0A48_14257	A0A1V8TUB6	A0A1V8SLU2	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	Uncharacterized protein.	0.893
B0A48_00319	B0A48_16238	A0A1V8TUB6	A0A1V8SFK4	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	ETF domain-containing protein.	0.535
B0A48_01126	B0A48_00319	A0A1V8TSC1	A0A1V8TUB6	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.953
B0A48_01126	B0A48_01908	A0A1V8TSC1	A0A1V8TQM2	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	ETF domain-containing protein.	0.535
B0A48_01126	B0A48_02216	A0A1V8TSC1	A0A1V8TNG7	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	Uncharacterized protein.	0.945
B0A48_01126	B0A48_06548	A0A1V8TSC1	A0A1V8TBQ8	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	Uncharacterized protein.	0.944
B0A48_01126	B0A48_07627	A0A1V8TSC1	A0A1V8T715	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	ETF domain-containing protein.	0.659
B0A48_01126	B0A48_09066	A0A1V8TSC1	A0A1V8T249	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.953
B0A48_01126	B0A48_11765	A0A1V8TSC1	A0A1V8ST76	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	ETF domain-containing protein.	0.659
B0A48_01126	B0A48_11954	A0A1V8TSC1	A0A1V8STA5	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.953
B0A48_01126	B0A48_14257	A0A1V8TSC1	A0A1V8SLU2	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	Uncharacterized protein.	0.893
B0A48_01126	B0A48_16238	A0A1V8TSC1	A0A1V8SFK4	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	ETF domain-containing protein.	0.535

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

41

average node degree:

7.45

avg. local clustering coefficient:

0.855

expected number of edges:

13

PPI enrichment p-value:

2.76e-10

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:2000272

Negative regulation of signaling receptor activity

3 of 4

3.06

2.55

2.32e-05

GO:0050730

Regulation of peptidyl-tyrosine phosphorylation

3 of 5

2.96

2.54

2.32e-05

GO:0007166

Cell surface receptor signaling pathway

5 of 147

1.72

1.98

2.64e-05

GO:0006469

Negative regulation of protein kinase activity

3 of 19

2.38

1.97

0.00020

GO:0048585

Negative regulation of response to stimulus

4 of 87

1.85

1.76

0.00020

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016755

Aminoacyltransferase activity

3 of 7

2.82

2.42

3.67e-05

GO:0017124

SH3 domain binding

3 of 9

2.71

2.41

3.67e-05

GO:0001784

Phosphotyrosine residue binding

3 of 11

2.62

2.39

3.67e-05

GO:0005102

Signaling receptor binding

4 of 59

2.02

2.17

3.67e-05

GO:0019901

Protein kinase binding

3 of 76

1.78

1.25

0.0029

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045121

Membrane raft

3 of 11

2.62

2.29

5.72e-05

GO:0071944

Cell periphery

5 of 929

0.92

0.49

0.0458

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:662

Mixed, incl. Regulation of cell migration, and Protein tyrosine kinase activity

6 of 61

2.18

4.03

2.71e-09

CL:685

Phosphotyrosine residue binding, and Transmembrane receptor protein kinase activity

3 of 20

2.36

2.07

0.00012

CL:768

VHS domain, and Semaphorin interactions

2 of 5

2.79

1.61

0.0012

CL:688

Mixed, incl. Phosphotyrosine residue binding, and Basal plasma membrane

2 of 13

2.37

1.22

0.0055

CL:1687

Mixed, incl. Protein tyrosine phosphatase, catalytic domain, and EGF-like domain

2 of 28

2.04

0.89

0.0212

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04144

Endocytosis

4 of 223

1.44

1.2

0.0013

map04120

Ubiquitin mediated proteolysis

3 of 173

1.42

0.87

0.0114

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0045121

Membrane raft

3 of 8

2.76

2.47

2.94e-05

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02761

CBL proto-oncogene N-terminus, EF hand-like domain

3 of 14

2.52

2.0

0.00019

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR024159

Adaptor protein Cbl, PTB domain

3 of 7

2.82

2.21

8.99e-05

IPR014741

Adaptor protein Cbl, EF hand-like

3 of 15

2.49

1.89

0.00030

IPR000980

SH2 domain

3 of 84

1.74

0.81

0.0257

IPR036860

SH2 domain superfamily

3 of 94

1.69

0.79

0.0268

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00252

Src homology 2 domains

3 of 93

1.69

0.96

0.0114

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