B0A48_12421 protein (Rachicladosporium antarcticum)

Nodes:

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Coexpression

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[Homology]

Score

B0A48_12421

Peptidylprolyl isomerase. (501 aa)

Predicted Functional Partners:

B0A48_08452

0.924

B0A48_04415

0.924

ERB1

0.900

ERB1-2

0.900

B0A48_10742

0.881

B0A48_08961

0.881

B0A48_17668

0.857

B0A48_15759

0.857

B0A48_13354

0.857

B0A48_09580

0.857

Your Current Organism:

Rachicladosporium antarcticum

NCBI taxonomy Id: 1507870
Other names: CCFEE 5527, R. antarcticum, Rachicladosporium antarcticum Onofri & Egidi, 2014

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B0A48_04415	B0A48_08961	A0A1V8TFA5	A0A1V8T5C4	Nucleolar protein 58.	Brix domain-containing protein.	0.943
B0A48_04415	B0A48_09580	A0A1V8TFA5	A0A1V8T0B6	Nucleolar protein 58.	Uncharacterized protein.	0.990
B0A48_04415	B0A48_10742	A0A1V8TFA5	A0A1V8SZ03	Nucleolar protein 58.	Brix domain-containing protein.	0.943
B0A48_04415	B0A48_12421	A0A1V8TFA5	A0A1V8SSF4	Nucleolar protein 58.	Peptidylprolyl isomerase.	0.924
B0A48_04415	B0A48_13354	A0A1V8TFA5	A0A1V8SQ33	Nucleolar protein 58.	Centromere/microtubule-binding protein cbf5.	0.990
B0A48_04415	ERB1	A0A1V8TFA5	A0A1V8T0Z7	Nucleolar protein 58.	Ribosome biogenesis protein ERB1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	0.984
B0A48_04415	ERB1-2	A0A1V8TFA5	A0A1V8TLQ1	Nucleolar protein 58.	Ribosome biogenesis protein ERB1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	0.984
B0A48_08452	B0A48_08961	A0A1V8T5H7	A0A1V8T5C4	Nucleolar protein 58.	Brix domain-containing protein.	0.943
B0A48_08452	B0A48_09580	A0A1V8T5H7	A0A1V8T0B6	Nucleolar protein 58.	Uncharacterized protein.	0.990
B0A48_08452	B0A48_10742	A0A1V8T5H7	A0A1V8SZ03	Nucleolar protein 58.	Brix domain-containing protein.	0.943
B0A48_08452	B0A48_12421	A0A1V8T5H7	A0A1V8SSF4	Nucleolar protein 58.	Peptidylprolyl isomerase.	0.924
B0A48_08452	B0A48_13354	A0A1V8T5H7	A0A1V8SQ33	Nucleolar protein 58.	Centromere/microtubule-binding protein cbf5.	0.990
B0A48_08452	ERB1	A0A1V8T5H7	A0A1V8T0Z7	Nucleolar protein 58.	Ribosome biogenesis protein ERB1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	0.984
B0A48_08452	ERB1-2	A0A1V8T5H7	A0A1V8TLQ1	Nucleolar protein 58.	Ribosome biogenesis protein ERB1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	0.984
B0A48_08961	B0A48_04415	A0A1V8T5C4	A0A1V8TFA5	Brix domain-containing protein.	Nucleolar protein 58.	0.943
B0A48_08961	B0A48_08452	A0A1V8T5C4	A0A1V8T5H7	Brix domain-containing protein.	Nucleolar protein 58.	0.943
B0A48_08961	B0A48_09580	A0A1V8T5C4	A0A1V8T0B6	Brix domain-containing protein.	Uncharacterized protein.	0.891
B0A48_08961	B0A48_12421	A0A1V8T5C4	A0A1V8SSF4	Brix domain-containing protein.	Peptidylprolyl isomerase.	0.881
B0A48_08961	B0A48_13354	A0A1V8T5C4	A0A1V8SQ33	Brix domain-containing protein.	Centromere/microtubule-binding protein cbf5.	0.891
B0A48_08961	ERB1	A0A1V8T5C4	A0A1V8T0Z7	Brix domain-containing protein.	Ribosome biogenesis protein ERB1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	0.989

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Network Stats

number of nodes:

11

number of edges:

30

average node degree:

5.45

avg. local clustering coefficient:

0.575

expected number of edges:

16

PPI enrichment p-value:

0.000764

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

9 of 318

1.64

3.24

5.95e-11

GO:0042273

Ribosomal large subunit biogenesis

4 of 71

1.94

2.17

2.90e-05

GO:0006417

Regulation of translation

4 of 157

1.6

1.47

0.00042

GO:0042254

Ribosome biogenesis

5 of 313

1.4

1.41

0.00017

GO:0044260

Cellular macromolecule metabolic process

10 of 1432

1.04

1.26

7.27e-08

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

6 of 176

1.72

2.45

9.86e-07

GO:0003746

Translation elongation factor activity

2 of 12

2.41

1.01

0.0143

GO:0003723

RNA binding

5 of 624

1.1

0.69

0.0142

GO:0003676

Nucleic acid binding

6 of 1481

0.8

0.44

0.0450

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0022625

Cytosolic large ribosomal subunit

5 of 51

2.18

3.49

5.97e-08

GO:0015934

Large ribosomal subunit

6 of 98

1.98

3.43

1.65e-08

GO:1990904

Ribonucleoprotein complex

7 of 481

1.36

1.83

6.13e-07

GO:0005829

Cytosol

6 of 1037

0.95

0.77

0.0017

GO:0032991

Protein-containing complex

8 of 1995

0.8

0.67

0.00049

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7510

Cytosolic ribosome, and Formation of the ternary complex, and subsequently, the 43S complex

8 of 106

2.07

4.99

1.18e-12

CL:7516

Cytosolic ribosome

6 of 95

1.99

3.7

3.05e-09

CL:7531

Cytosolic ribosome

4 of 61

2.01

2.41

9.90e-06

CL:7922

Mixed, incl. Elongation factor Tu C-terminal domain, and IQ motif, EF-hand binding site

2 of 5

2.79

1.65

0.0010

CL:7711

Mixed, incl. Ribosomal protein L7/L30, and Sec61 translocon complex

2 of 5

2.79

1.65

0.0010

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03010

Ribosome

6 of 200

1.67

2.55

1.90e-07

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-72766

Translation

8 of 291

1.63

2.96

1.19e-09

MAP-1799339

SRP-dependent cotranslational protein targeting to membrane

6 of 145

1.81

2.89

9.06e-08

MAP-72706

GTP hydrolysis and joining of the 60S ribosomal subunit

5 of 134

1.76

2.29

4.64e-06

MAP-72689

Formation of a pool of free 40S subunits

5 of 143

1.74

2.25

4.78e-06

MAP-975956

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

5 of 145

1.73

2.24

4.78e-06

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0022625

Cytosolic large ribosomal subunit

5 of 45

2.24

3.75

1.99e-08

GOCC:0015934

Large ribosomal subunit

6 of 85

2.04

3.74

4.35e-09

GOCC:0022626

Cytosolic ribosome

6 of 90

2.02

3.69

4.35e-09

GOCC:0005840

Ribosome

7 of 161

1.83

3.39

2.48e-09

GOCC:0005829

Cytosol

7 of 453

1.38

1.89

4.87e-07

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

3 of 103

1.66

0.99

0.0092

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR047038

Elongation Factor 3, chromodomain-like insertion superfamily

2 of 2

3.19

1.19

0.0072

IPR021133

HEAT, type 2

2 of 11

2.45

0.82

0.0323

IPR008991

Translation protein SH3-like domain superfamily

2 of 13

2.38

0.82

0.0323

IPR011989

Armadillo-like helical

3 of 84

1.75

0.76

0.0323

IPR016024

Armadillo-type fold

3 of 125

1.57

0.69

0.0411

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