B0A48_02986 protein (Rachicladosporium antarcticum)

Nodes:

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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Textmining

[Homology]

Score

B0A48_02986

Uncharacterized protein. (310 aa)

Predicted Functional Partners:

B0A48_18187

0.857

B0A48_16833

0.857

B0A48_17495

0.854

B0A48_16561

0.854

B0A48_07781

0.854

B0A48_00048

0.854

B0A48_07847

0.839

B0A48_02644

0.839

B0A48_11330

0.818

B0A48_08994

0.818

Your Current Organism:

Rachicladosporium antarcticum

NCBI taxonomy Id: 1507870
Other names: CCFEE 5527, R. antarcticum, Rachicladosporium antarcticum Onofri & Egidi, 2014

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B0A48_00048	B0A48_02644	A0A1V8TTM2	A0A1V8TKW1	TLC domain-containing protein.	DAGKc domain-containing protein.	0.830
B0A48_00048	B0A48_02986	A0A1V8TTM2	A0A1V8TM09	TLC domain-containing protein.	Uncharacterized protein.	0.854
B0A48_00048	B0A48_07847	A0A1V8TTM2	A0A1V8T0H4	TLC domain-containing protein.	DAGKc domain-containing protein.	0.830
B0A48_00048	B0A48_08994	A0A1V8TTM2	A0A1V8T1F1	TLC domain-containing protein.	Sphingolipid delta(4)-desaturase; Delta(4)-fatty-acid desaturase which introduces a double bond at the 4-position in the long-chain base (LCB) of ceramides.	0.846
B0A48_00048	B0A48_11330	A0A1V8TTM2	A0A1V8SV68	TLC domain-containing protein.	Lipid_DES domain-containing protein.	0.846
B0A48_00048	B0A48_16833	A0A1V8TTM2	A0A1V8SD81	TLC domain-containing protein.	Neutral ceramidase.	0.824
B0A48_00048	B0A48_18187	A0A1V8TTM2	A0A1V8S9D2	TLC domain-containing protein.	Neutral ceramidase.	0.824
B0A48_02644	B0A48_00048	A0A1V8TKW1	A0A1V8TTM2	DAGKc domain-containing protein.	TLC domain-containing protein.	0.830
B0A48_02644	B0A48_02986	A0A1V8TKW1	A0A1V8TM09	DAGKc domain-containing protein.	Uncharacterized protein.	0.839
B0A48_02644	B0A48_07781	A0A1V8TKW1	A0A1V8T7H5	DAGKc domain-containing protein.	TLC domain-containing protein.	0.830
B0A48_02644	B0A48_08994	A0A1V8TKW1	A0A1V8T1F1	DAGKc domain-containing protein.	Sphingolipid delta(4)-desaturase; Delta(4)-fatty-acid desaturase which introduces a double bond at the 4-position in the long-chain base (LCB) of ceramides.	0.872
B0A48_02644	B0A48_11330	A0A1V8TKW1	A0A1V8SV68	DAGKc domain-containing protein.	Lipid_DES domain-containing protein.	0.872
B0A48_02644	B0A48_16561	A0A1V8TKW1	A0A1V8SE11	DAGKc domain-containing protein.	TLC domain-containing protein.	0.830
B0A48_02644	B0A48_16833	A0A1V8TKW1	A0A1V8SD81	DAGKc domain-containing protein.	Neutral ceramidase.	0.879
B0A48_02644	B0A48_17495	A0A1V8TKW1	A0A1V8SBJ5	DAGKc domain-containing protein.	TLC domain-containing protein.	0.830
B0A48_02644	B0A48_18187	A0A1V8TKW1	A0A1V8S9D2	DAGKc domain-containing protein.	Neutral ceramidase.	0.879
B0A48_02986	B0A48_00048	A0A1V8TM09	A0A1V8TTM2	Uncharacterized protein.	TLC domain-containing protein.	0.854
B0A48_02986	B0A48_02644	A0A1V8TM09	A0A1V8TKW1	Uncharacterized protein.	DAGKc domain-containing protein.	0.839
B0A48_02986	B0A48_07781	A0A1V8TM09	A0A1V8T7H5	Uncharacterized protein.	TLC domain-containing protein.	0.854
B0A48_02986	B0A48_07847	A0A1V8TM09	A0A1V8T0H4	Uncharacterized protein.	DAGKc domain-containing protein.	0.839

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

49

average node degree:

8.91

avg. local clustering coefficient:

0.921

expected number of edges:

15

PPI enrichment p-value:

9.92e-13

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006085

acetyl-CoA biosynthetic process

4 of 8

2.23

2.36

2.51e-05

GO:0019427

acetyl-CoA biosynthetic process from acetate

2 of 3

2.35

1.28

0.0042

GO:0022900

Electron transport chain

5 of 96

1.25

1.14

0.00052

GO:0006091

Generation of precursor metabolites and energy

6 of 184

1.04

0.93

0.00054

GO:0032787

Monocarboxylic acid metabolic process

4 of 113

1.08

0.72

0.0097

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030976

Thiamine pyrophosphate binding

4 of 8

2.23

2.49

1.32e-05

GO:0016208

AMP binding

2 of 3

2.35

1.15

0.0074

GO:0003987

acetate-CoA ligase activity

2 of 3

2.35

1.15

0.0074

GO:0043169

Cation binding

8 of 564

0.68

0.51

0.0037

GO:0036094

Small molecule binding

8 of 556

0.69

0.51

0.0037

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009274

Peptidoglycan-based cell wall

3 of 22

1.66

1.09

0.0055

GO:0005829

Cytosol

6 of 316

0.81

0.58

0.0065

GO:0005737

Cytoplasm

9 of 1132

0.43

0.31

0.0214

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1244

Citrate cycle (TCA cycle), and Propanoate metabolism

10 of 30

2.05

6.17

5.15e-17

CL:1245

Citrate cycle (TCA cycle)

6 of 23

1.95

3.42

1.14e-08

CL:1246

Citrate cycle (TCA cycle), and Novobiocin biosynthesis

5 of 14

2.08

3.23

1.40e-07

CL:1292

acetyl-CoA biosynthetic process

4 of 5

2.43

3.2

6.81e-07

CL:1248

Pyruvate ferredoxin/flavodoxin oxidoreductase, and Thiamine pyrophosphate enzyme, TPP-binding

4 of 7

2.29

2.96

1.52e-06

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

daf00620

Pyruvate metabolism

11 of 38

1.99

6.53

6.02e-20

daf00650

Butanoate metabolism

5 of 14

2.08

3.58

1.76e-08

daf01200

Carbon metabolism

11 of 115

1.51

3.3

2.10e-15

daf00010

Glycolysis / Gluconeogenesis

7 of 46

1.71

3.24

6.14e-10

daf00020

Citrate cycle (TCA cycle)

5 of 22

1.89

3.03

8.64e-08

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005618

Cell wall

3 of 12

1.93

1.34

0.0023

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0460

Magnesium

4 of 98

1.14

0.71

0.0154

KW-0479

Metal-binding

6 of 263

0.89

0.61

0.0093

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02775

Thiamine pyrophosphate enzyme, C-terminal TPP binding domain

4 of 7

2.29

2.62

7.79e-06

PF01855

Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg

2 of 5

2.13

0.71

0.0481

PF01558

Pyruvate ferredoxin/flavodoxin oxidoreductase

2 of 5

2.13

0.71

0.0481

PF13193

AMP-binding enzyme C-terminal domain

2 of 7

1.99

0.7

0.0481

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR029061

Thiamin diphosphate-binding fold

5 of 16

2.02

2.68

2.24e-06

IPR011766

Thiamine pyrophosphate enzyme, TPP-binding

4 of 7

2.29

2.58

9.79e-06

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