B0A48_00817 protein (Rachicladosporium antarcticum)

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second shell of interactors

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Known Interactions

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Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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[Homology]

Score

B0A48_00817

Uncharacterized protein. (725 aa)

Predicted Functional Partners:

B0A48_14808

0.853

B0A48_14146

0.853

B0A48_13972

0.653

B0A48_15857

0.539

B0A48_17516

0.513

B0A48_07803

0.513

NTH1

0.474

B0A48_00005

0.474

B0A48_18474

0.468

B0A48_18606

0.468

Your Current Organism:

Rachicladosporium antarcticum

NCBI taxonomy Id: 1507870
Other names: CCFEE 5527, R. antarcticum, Rachicladosporium antarcticum Onofri & Egidi, 2014

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B0A48_00005	B0A48_00817	A0A1V8TTG5	A0A1V8TRV8	5'-3' exoribonuclease; Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.	Uncharacterized protein.	0.474
B0A48_00005	B0A48_07803	A0A1V8TTG5	A0A1V8T747	5'-3' exoribonuclease; Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.	Uncharacterized protein.	0.497
B0A48_00005	B0A48_14146	A0A1V8TTG5	A0A1V8SM33	5'-3' exoribonuclease; Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.	CID domain-containing protein.	0.628
B0A48_00005	B0A48_14808	A0A1V8TTG5	A0A1V8SKH6	5'-3' exoribonuclease; Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.	CID domain-containing protein.	0.628
B0A48_00005	B0A48_15857	A0A1V8TTG5	A0A1V8S9T4	5'-3' exoribonuclease; Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.	Nuclear cap-binding protein subunit 2.	0.563
B0A48_00005	B0A48_17516	A0A1V8TTG5	A0A1V8SC12	5'-3' exoribonuclease; Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.	Uncharacterized protein.	0.497
B0A48_00005	B0A48_18474	A0A1V8TTG5	A0A1V8S822	5'-3' exoribonuclease; Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.	Transcription elongation factor SPT5; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.	0.476
B0A48_00005	B0A48_18606	A0A1V8TTG5	A0A1V8S8C3	5'-3' exoribonuclease; Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.	Transcription elongation factor SPT5; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.	0.476
B0A48_00817	B0A48_00005	A0A1V8TRV8	A0A1V8TTG5	Uncharacterized protein.	5'-3' exoribonuclease; Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.	0.474
B0A48_00817	B0A48_07803	A0A1V8TRV8	A0A1V8T747	Uncharacterized protein.	Uncharacterized protein.	0.513
B0A48_00817	B0A48_13972	A0A1V8TRV8	A0A1V8SM00	Uncharacterized protein.	Sister chromatid cohesion protein.	0.653
B0A48_00817	B0A48_14146	A0A1V8TRV8	A0A1V8SM33	Uncharacterized protein.	CID domain-containing protein.	0.853
B0A48_00817	B0A48_14808	A0A1V8TRV8	A0A1V8SKH6	Uncharacterized protein.	CID domain-containing protein.	0.853
B0A48_00817	B0A48_15857	A0A1V8TRV8	A0A1V8S9T4	Uncharacterized protein.	Nuclear cap-binding protein subunit 2.	0.539
B0A48_00817	B0A48_17516	A0A1V8TRV8	A0A1V8SC12	Uncharacterized protein.	Uncharacterized protein.	0.513
B0A48_00817	B0A48_18474	A0A1V8TRV8	A0A1V8S822	Uncharacterized protein.	Transcription elongation factor SPT5; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.	0.468
B0A48_00817	B0A48_18606	A0A1V8TRV8	A0A1V8S8C3	Uncharacterized protein.	Transcription elongation factor SPT5; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.	0.468
B0A48_00817	NTH1	A0A1V8TRV8	A0A1V8T500	Uncharacterized protein.	Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.	0.474
B0A48_07803	B0A48_00005	A0A1V8T747	A0A1V8TTG5	Uncharacterized protein.	5'-3' exoribonuclease; Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.	0.497
B0A48_07803	B0A48_00817	A0A1V8T747	A0A1V8TRV8	Uncharacterized protein.	Uncharacterized protein.	0.513

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

53

average node degree:

9.64

avg. local clustering coefficient:

0.968

expected number of edges:

18

PPI enrichment p-value:

1.99e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006633

Fatty acid biosynthetic process

10 of 71

1.76

4.29

2.68e-14

GO:0044238

Primary metabolic process

11 of 1619

0.45

0.37

0.00093

GO:0071704

Organic substance metabolic process

11 of 2102

0.33

0.27

0.0154

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004312

Fatty acid synthase activity

6 of 29

1.93

3.36

1.49e-08

GO:0016747

Acyltransferase activity, transferring groups other than amino-acyl groups

9 of 134

1.44

2.44

9.17e-10

GO:0004315

3-oxoacyl-[acyl-carrier-protein] synthase activity

4 of 21

1.9

2.06

4.29e-05

GO:0031177

Phosphopantetheine binding

3 of 22

1.75

1.23

0.0029

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

10 of 1411

0.47

0.35

0.0094

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2485

Biotin metabolism

8 of 12

2.44

7.06

1.27e-15

CL:2479

Fatty acid biosynthesis, and Acetyl-CoA carboxylase

9 of 33

2.05

5.75

1.86e-15

CL:2487

Beta-ketoacyl synthase, and Fatty acid biosynthesis

5 of 5

2.62

4.73

8.33e-10

CL:2359

Mixed, incl. Fatty acid biosynthetic process, and AMP-dependent synthetase/ligase domain

11 of 93

1.69

4.2

5.49e-16

CL:2499

Beta-ketoacyl synthase, and Fatty acid synthase complex

2 of 5

2.22

1.04

0.0116

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

stp00061

Fatty acid biosynthesis

9 of 36

2.01

5.56

2.52e-15

stp01212

Fatty acid metabolism

9 of 54

1.84

4.58

3.34e-14

stp00780

Biotin metabolism

6 of 24

2.01

3.93

8.69e-10

stp01100

Metabolic pathways

9 of 804

0.66

0.57

0.00021

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005835

Fatty acid synthase complex

5 of 24

1.93

2.72

1.03e-06

GOCC:0032991

Protein-containing complex

8 of 625

0.72

0.57

0.0016

GOCC:0005737

Cytoplasm

11 of 1265

0.55

0.48

0.00013

GOCC:0005829

Cytosol

6 of 496

0.7

0.42

0.0312

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0275

Fatty acid biosynthesis

2 of 8

2.01

0.86

0.0245

KW-0808

Transferase

7 of 531

0.74

0.49

0.0139

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF08545

3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III

2 of 2

2.62

1.09

0.0103

PF00109

Beta-ketoacyl synthase, N-terminal domain

3 of 17

1.86

1.08

0.0076

PF00698

Acyl transferase domain

2 of 4

2.31

0.96

0.0171

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR016039

Thiolase-like

5 of 36

1.76

1.98

3.44e-05

IPR014030

Beta-ketoacyl synthase, N-terminal

4 of 22

1.87

1.75

0.00023

IPR000794

Beta-ketoacyl synthase

3 of 10

2.09

1.44

0.0017

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