node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CBH21558.1 | CBH22070.1 | CLOST_1438 | CLOST_1950 | FAD-dependent pyridine nucleotide-disulphide oxidoreductase. | Pyridine nucleotide-disulphide oxidoreductase family protein. | 0.729 |
CBH21558.1 | arsC | CLOST_1438 | CLOST_1874 | FAD-dependent pyridine nucleotide-disulphide oxidoreductase. | Protein arsC (Arsenate reductase) (Arsenical pump modifier) (Low molecular weight protein-tyrosine-phosphatase). | 0.679 |
CBH21558.1 | grdA | CLOST_1438 | CLOST_1112 | FAD-dependent pyridine nucleotide-disulphide oxidoreductase. | Glycine reductase component A selenoprotein; In the first step of glycine, betaine and sarcosine reductases, the substrate is bound to component PB via a Schiff base intermediate. Then the PB-activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a carboxymethylated selenoether and the respective amine. By action of component PC, acetyl phosphate is formed, leaving component PA in its oxidized state. Finally component PA becomes reduced by the thioredoxin system to start a new catalytic cycle of reductive deamination. | 0.590 |
CBH21558.1 | trxA | CLOST_1438 | CLOST_1109 | FAD-dependent pyridine nucleotide-disulphide oxidoreductase. | Thioredoxin (Trx); Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. | 0.873 |
CBH21558.1 | trxB | CLOST_1438 | CLOST_1108 | FAD-dependent pyridine nucleotide-disulphide oxidoreductase. | Thioredoxin reductase. | 0.974 |
CBH22070.1 | CBH21558.1 | CLOST_1950 | CLOST_1438 | Pyridine nucleotide-disulphide oxidoreductase family protein. | FAD-dependent pyridine nucleotide-disulphide oxidoreductase. | 0.729 |
CBH22070.1 | trxA | CLOST_1950 | CLOST_1109 | Pyridine nucleotide-disulphide oxidoreductase family protein. | Thioredoxin (Trx); Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. | 0.808 |
arsC | CBH21558.1 | CLOST_1874 | CLOST_1438 | Protein arsC (Arsenate reductase) (Arsenical pump modifier) (Low molecular weight protein-tyrosine-phosphatase). | FAD-dependent pyridine nucleotide-disulphide oxidoreductase. | 0.679 |
arsC | trxA | CLOST_1874 | CLOST_1109 | Protein arsC (Arsenate reductase) (Arsenical pump modifier) (Low molecular weight protein-tyrosine-phosphatase). | Thioredoxin (Trx); Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. | 0.777 |
grdA | CBH21558.1 | CLOST_1112 | CLOST_1438 | Glycine reductase component A selenoprotein; In the first step of glycine, betaine and sarcosine reductases, the substrate is bound to component PB via a Schiff base intermediate. Then the PB-activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a carboxymethylated selenoether and the respective amine. By action of component PC, acetyl phosphate is formed, leaving component PA in its oxidized state. Finally component PA becomes reduced by the thioredoxin system to start a new catalytic cycle of reductive deamination. | FAD-dependent pyridine nucleotide-disulphide oxidoreductase. | 0.590 |
grdA | grdB | CLOST_1112 | CLOST_1113 | Glycine reductase component A selenoprotein; In the first step of glycine, betaine and sarcosine reductases, the substrate is bound to component PB via a Schiff base intermediate. Then the PB-activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a carboxymethylated selenoether and the respective amine. By action of component PC, acetyl phosphate is formed, leaving component PA in its oxidized state. Finally component PA becomes reduced by the thioredoxin system to start a new catalytic cycle of reductive deamination. | Glycine reductase component B (47 kDa, subunit gamma); Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.984 |
grdA | grdC | CLOST_1112 | CLOST_1115 | Glycine reductase component A selenoprotein; In the first step of glycine, betaine and sarcosine reductases, the substrate is bound to component PB via a Schiff base intermediate. Then the PB-activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a carboxymethylated selenoether and the respective amine. By action of component PC, acetyl phosphate is formed, leaving component PA in its oxidized state. Finally component PA becomes reduced by the thioredoxin system to start a new catalytic cycle of reductive deamination. | Glycine reductase component C subunit beta; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.930 |
grdA | grdD | CLOST_1112 | CLOST_1116 | Glycine reductase component A selenoprotein; In the first step of glycine, betaine and sarcosine reductases, the substrate is bound to component PB via a Schiff base intermediate. Then the PB-activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a carboxymethylated selenoether and the respective amine. By action of component PC, acetyl phosphate is formed, leaving component PA in its oxidized state. Finally component PA becomes reduced by the thioredoxin system to start a new catalytic cycle of reductive deamination. | Glycine reductase component C subunit alpha; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.917 |
grdA | grdE | CLOST_1112 | CLOST_1110 | Glycine reductase component A selenoprotein; In the first step of glycine, betaine and sarcosine reductases, the substrate is bound to component PB via a Schiff base intermediate. Then the PB-activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a carboxymethylated selenoether and the respective amine. By action of component PC, acetyl phosphate is formed, leaving component PA in its oxidized state. Finally component PA becomes reduced by the thioredoxin system to start a new catalytic cycle of reductive deamination. | Glycine reductase complex component B subunits alpha and beta; In the first step of glycine reductase, the substrate is bound to component PB via a Schiff base intermediate. Then the PB- activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a carboxymethylated selenoether and the respective amine. By action of component PC, acetyl phosphate is formed, leaving component PA in its oxidized state. Finally component PA becomes reduced by the thioredoxin system to start a new catalytic cycle of reductive deamination (By similarity). | 0.945 |
grdA | grdX | CLOST_1112 | CLOST_1107 | Glycine reductase component A selenoprotein; In the first step of glycine, betaine and sarcosine reductases, the substrate is bound to component PB via a Schiff base intermediate. Then the PB-activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a carboxymethylated selenoether and the respective amine. By action of component PC, acetyl phosphate is formed, leaving component PA in its oxidized state. Finally component PA becomes reduced by the thioredoxin system to start a new catalytic cycle of reductive deamination. | GrdX protein; Function of strongly homologous gene; putative regulator. | 0.894 |
grdA | trxA | CLOST_1112 | CLOST_1109 | Glycine reductase component A selenoprotein; In the first step of glycine, betaine and sarcosine reductases, the substrate is bound to component PB via a Schiff base intermediate. Then the PB-activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a carboxymethylated selenoether and the respective amine. By action of component PC, acetyl phosphate is formed, leaving component PA in its oxidized state. Finally component PA becomes reduced by the thioredoxin system to start a new catalytic cycle of reductive deamination. | Thioredoxin (Trx); Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. | 0.954 |
grdA | trxB | CLOST_1112 | CLOST_1108 | Glycine reductase component A selenoprotein; In the first step of glycine, betaine and sarcosine reductases, the substrate is bound to component PB via a Schiff base intermediate. Then the PB-activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a carboxymethylated selenoether and the respective amine. By action of component PC, acetyl phosphate is formed, leaving component PA in its oxidized state. Finally component PA becomes reduced by the thioredoxin system to start a new catalytic cycle of reductive deamination. | Thioredoxin reductase. | 0.858 |
grdB | grdA | CLOST_1113 | CLOST_1112 | Glycine reductase component B (47 kDa, subunit gamma); Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Glycine reductase component A selenoprotein; In the first step of glycine, betaine and sarcosine reductases, the substrate is bound to component PB via a Schiff base intermediate. Then the PB-activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a carboxymethylated selenoether and the respective amine. By action of component PC, acetyl phosphate is formed, leaving component PA in its oxidized state. Finally component PA becomes reduced by the thioredoxin system to start a new catalytic cycle of reductive deamination. | 0.984 |
grdB | grdC | CLOST_1113 | CLOST_1115 | Glycine reductase component B (47 kDa, subunit gamma); Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Glycine reductase component C subunit beta; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.929 |
grdB | grdD | CLOST_1113 | CLOST_1116 | Glycine reductase component B (47 kDa, subunit gamma); Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Glycine reductase component C subunit alpha; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.925 |