STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
grdAGlycine reductase component A selenoprotein; In the first step of glycine, betaine and sarcosine reductases, the substrate is bound to component PB via a Schiff base intermediate. Then the PB-activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a carboxymethylated selenoether and the respective amine. By action of component PC, acetyl phosphate is formed, leaving component PA in its oxidized state. Finally component PA becomes reduced by the thioredoxin system to start a new catalytic cycle of reductive deamination. (158 aa)    
Predicted Functional Partners:
grdB
Glycine reductase component B (47 kDa, subunit gamma); Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
  
 0.984
trxA
Thioredoxin (Trx); Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
 
   
 0.954
grdE
Glycine reductase complex component B subunits alpha and beta; In the first step of glycine reductase, the substrate is bound to component PB via a Schiff base intermediate. Then the PB- activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a carboxymethylated selenoether and the respective amine. By action of component PC, acetyl phosphate is formed, leaving component PA in its oxidized state. Finally component PA becomes reduced by the thioredoxin system to start a new catalytic cycle of reductive deamination (By similarity).
 
   
 0.945
grdC
Glycine reductase component C subunit beta; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
   
 0.930
grdD
Glycine reductase component C subunit alpha; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
   
 0.917
grdH
Betaine reductase complex component B subunit beta (Selenoprotein PB beta); Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
   
 0.912
grdX
GrdX protein; Function of strongly homologous gene; putative regulator.
 
   
 0.894
trxB
Thioredoxin reductase.
 
   
 0.858
grdI
Betaine reductase complex component B subunit alpha (Selenoprotein PB alpha).
 
   
 0.857
pdrB
D-proline reductase gamma chain; D-proline reductase catalyzes the reductive cleavage of a C-N bond in D-proline resulting in the formation of 5-aminovalerate. The alpha subunit has been shown to bind D-proline, presumably via the pyruvoyl group.
 
   
 0.732
Your Current Organism:
Acetoanaerobium sticklandii
NCBI taxonomy Id: 1511
Other names: A. sticklandii, ATCC 12662, BCRC 14485, CCRC 14485, CCRC:14485, CCUG 9281, Clostridium sticklandii, DSM 519, NCIMB 10654, strain StadtmanHF
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