node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CBH20134.1 | CBH21376.1 | CLOST_0002 | CLOST_1256 | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Homologs of previously reported genes of unknown function. | 0.549 |
CBH20134.1 | CBH21388.1 | CLOST_0002 | CLOST_1268 | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Putative DNA-binding protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | 0.697 |
CBH20134.1 | CBH22030.1 | CLOST_0002 | CLOST_1910 | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Putative Helicase, UvrD/REP/exonuclease family protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | 0.871 |
CBH20134.1 | polA | CLOST_0002 | CLOST_1407 | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.995 |
CBH20134.1 | recD2 | CLOST_0002 | CLOST_2355 | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Putative DNA-binding protein; DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity; Belongs to the RecD family. RecD-like subfamily. | 0.697 |
CBH20134.1 | topA | CLOST_0002 | CLOST_1498 | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | TopA; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally [...] | 0.666 |
CBH21376.1 | CBH20134.1 | CLOST_1256 | CLOST_0002 | Homologs of previously reported genes of unknown function. | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.549 |
CBH21376.1 | CBH21388.1 | CLOST_1256 | CLOST_1268 | Homologs of previously reported genes of unknown function. | Putative DNA-binding protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | 0.435 |
CBH21376.1 | CBH22030.1 | CLOST_1256 | CLOST_1910 | Homologs of previously reported genes of unknown function. | Putative Helicase, UvrD/REP/exonuclease family protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | 0.718 |
CBH21376.1 | addA | CLOST_1256 | CLOST_0225 | Homologs of previously reported genes of unknown function. | ATP-dependent nuclease, subunit A; ATP-dependent DNA helicase. | 0.476 |
CBH21376.1 | polA | CLOST_1256 | CLOST_1407 | Homologs of previously reported genes of unknown function. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.937 |
CBH21376.1 | recD2 | CLOST_1256 | CLOST_2355 | Homologs of previously reported genes of unknown function. | Putative DNA-binding protein; DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity; Belongs to the RecD family. RecD-like subfamily. | 0.435 |
CBH21376.1 | topA | CLOST_1256 | CLOST_1498 | Homologs of previously reported genes of unknown function. | TopA; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally [...] | 0.906 |
CBH21387.1 | CBH21388.1 | CLOST_1267 | CLOST_1268 | Protein of unknown function; No homology to any previously reported sequences. | Putative DNA-binding protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | 0.487 |
CBH21387.1 | CBH21389.1 | CLOST_1267 | CLOST_1269 | Protein of unknown function; No homology to any previously reported sequences. | Protein of unknown function; No homology to any previously reported sequences. | 0.487 |
CBH21388.1 | CBH20134.1 | CLOST_1268 | CLOST_0002 | Putative DNA-binding protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.697 |
CBH21388.1 | CBH21376.1 | CLOST_1268 | CLOST_1256 | Putative DNA-binding protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | Homologs of previously reported genes of unknown function. | 0.435 |
CBH21388.1 | CBH21387.1 | CLOST_1268 | CLOST_1267 | Putative DNA-binding protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | Protein of unknown function; No homology to any previously reported sequences. | 0.487 |
CBH21388.1 | CBH21389.1 | CLOST_1268 | CLOST_1269 | Putative DNA-binding protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | Protein of unknown function; No homology to any previously reported sequences. | 0.773 |
CBH21388.1 | CBH21390.1 | CLOST_1268 | CLOST_1270 | Putative DNA-binding protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | Protein of unknown function; No homology to any previously reported sequences. | 0.510 |