STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
oraED-ornithine aminomutase E component; Component of a complex that catalyzes the reversible migration of the omega amino group of D-ornithine to C-4 to form (2R,4S)-2,4-diaminopentanoic acid. OraE may be the catalytic subunit. Active only on D-ornithine and 2,4-diaminopentanoic acid but not active on L-ornithine, L-beta-lysine, L-alpha-lysine or D-alpha-lysine. (740 aa)    
Predicted Functional Partners:
oraS
D-ornithine aminomutase S component; Component of a complex that catalyzes the reversible migration of the omega amino group of D-ornithine to C-4 to form (2R,4S)-2,4-diaminopentanoic acid. The role of OraS remains obscure; however, it seems to be required for a correct folding of the OraE subunit. The complex is active only on D-ornithine and 2,4- diaminopentanoic acid and not active on L-ornithine, L-beta-lysine, L- alpha-lysine or D-alpha-lysine.
 
 
 0.999
orr
Ornithine racemase; Involved in the ornithine fermentation pathway. Catalyzes the conversion of L-ornithine to D-ornithine. OR could also racemize basic amino acids such as lysine and arginine. Serine, asparagine and alanine could be also converted by OR, but at a lower rate.
 
  
 0.994
ord
(2R,4S)-2,4-diaminopentanoate dehydrogenase (DAPDH); Involved in the ornithine fermentation pathway. Catalyzes the oxidative deamination of (2R,4S)-2,4-diaminopentanoate (DAP) to yield 2-amino-4-ketopentanoate (AKP).
 
  
 0.991
CBH20175.1
Alanine racemase domain protein.
 
  
 0.973
CBH21409.1
Putative component of D-ornithine aminomutase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
 
     0.953
ortB
2-amino-4-ketopentanoate thiolase (AKPT) beta subunit; Involved in the ornithine fermentation pathway. Catalyzes the thiolytic cleavage of 2-amino-4-ketopentanoate (AKP) with coenzyme A (CoA) to form acetyl-CoA and alanine. It is strictly specific for AKP.
 
   
 0.939
ortA
2-amino-4-ketopentanoate thiolase (AKPT), alpha subunit; Involved in the ornithine fermentation pathway. Catalyzes the thiolytic cleavage of 2-amino-4-ketopentanoate (AKP) with coenzyme A (CoA) to form acetyl-CoA and alanine. It is strictly specific for AKP. Belongs to the OrtA family.
 
     0.934
CBH21501.1
Homologs of previously reported genes of unknown function.
 
     0.489
Your Current Organism:
Acetoanaerobium sticklandii
NCBI taxonomy Id: 1511
Other names: A. sticklandii, ATCC 12662, BCRC 14485, CCRC 14485, CCRC:14485, CCUG 9281, Clostridium sticklandii, DSM 519, NCIMB 10654, strain StadtmanHF
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