node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CBH21428.1 | apt | CLOST_1308 | CLOST_1306 | ABC-1 domain protein. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.741 |
CBH21428.1 | recJ | CLOST_1308 | CLOST_1307 | ABC-1 domain protein. | Putative single-stranded-DNA-specific exonuclease; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | 0.857 |
CBH21428.1 | secD | CLOST_1308 | CLOST_1310 | ABC-1 domain protein. | Protein-export membrane protein SecD precursor; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | 0.553 |
CBH21428.1 | secF | CLOST_1308 | CLOST_1309 | ABC-1 domain protein. | SecYEG protein translocase auxillary subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | 0.562 |
CBH21619.1 | recJ | CLOST_1499 | CLOST_1307 | DNA processing protein (smf family) (modular protein). | Putative single-stranded-DNA-specific exonuclease; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | 0.592 |
CBH21619.1 | topA | CLOST_1499 | CLOST_1498 | DNA processing protein (smf family) (modular protein). | TopA; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally [...] | 0.908 |
CBH22622.1 | mutL | CLOST_2507 | CLOST_1229 | ATP-dependent DNA helicase. | DNA mismatch repair protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.804 |
CBH22622.1 | polA | CLOST_2507 | CLOST_1407 | ATP-dependent DNA helicase. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.901 |
CBH22622.1 | recJ | CLOST_2507 | CLOST_1307 | ATP-dependent DNA helicase. | Putative single-stranded-DNA-specific exonuclease; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | 0.939 |
CBH22622.1 | topA | CLOST_2507 | CLOST_1498 | ATP-dependent DNA helicase. | TopA; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally [...] | 0.899 |
apt | CBH21428.1 | CLOST_1306 | CLOST_1308 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | ABC-1 domain protein. | 0.741 |
apt | polA | CLOST_1306 | CLOST_1407 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.438 |
apt | recJ | CLOST_1306 | CLOST_1307 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Putative single-stranded-DNA-specific exonuclease; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | 0.818 |
apt | secD | CLOST_1306 | CLOST_1310 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Protein-export membrane protein SecD precursor; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | 0.517 |
apt | secF | CLOST_1306 | CLOST_1309 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | SecYEG protein translocase auxillary subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | 0.525 |
mutL | CBH22622.1 | CLOST_1229 | CLOST_2507 | DNA mismatch repair protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | ATP-dependent DNA helicase. | 0.804 |
mutL | polA | CLOST_1229 | CLOST_1407 | DNA mismatch repair protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.980 |
mutL | priA | CLOST_1229 | CLOST_1857 | DNA mismatch repair protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | Primosome assembly protein PriA; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. | 0.531 |
mutL | recJ | CLOST_1229 | CLOST_1307 | DNA mismatch repair protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | Putative single-stranded-DNA-specific exonuclease; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | 0.620 |
mutL | topA | CLOST_1229 | CLOST_1498 | DNA mismatch repair protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | TopA; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally [...] | 0.450 |