STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
thiCThiamine biosynthesis protein thiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (436 aa)    
Predicted Functional Partners:
thiD
Bifunctional hydroxy-methylpyrimidine kinase and hydroxy-phosphomethylpyrimidine kinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
 0.998
thiE
Thiamin phosphate synthase (thiamin phosphate pyrophosphorylase); Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
  
 0.997
hydG
Fe-hydrogenase assembly protein; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
  
 0.970
thiM
Hydoxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family.
  
  
 0.911
purM
Phosphoribosylaminoimidazole synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
     
 0.806
moeB
Molybdopterin biosynthesis protein MoeB.
  
  
 0.727
CBH22131.1
ThiW protein precursor.
       0.678
hydE
Iron-only hydrogenase maturation protein; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
  
  
 0.508
purD
Phosphoribosylamine--glycine ligase (modular protein); Belongs to the GARS family.
  
  
 0.495
CBH21122.1
Uroporphyrinogen III synthase/methyltransferase.
  
  
 0.474
Your Current Organism:
Acetoanaerobium sticklandii
NCBI taxonomy Id: 1511
Other names: A. sticklandii, ATCC 12662, BCRC 14485, CCRC 14485, CCRC:14485, CCUG 9281, Clostridium sticklandii, DSM 519, NCIMB 10654, strain StadtmanHF
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