STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
trpBUnannotated protein; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (394 aa)    
Predicted Functional Partners:
trpC
Unannotated protein; Belongs to the TrpC family.
 
 0.999
trpA
Unannotated protein; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
 0.999
trpF
Unannotated protein; Belongs to the TrpF family.
 
 0.998
trpD
Unannotated protein; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA).
 
 
 0.997
E7GHF5_CLOSY
Unannotated protein.
 
 
 0.980
trpE
Unannotated protein; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.
 
  
 0.978
E7GHZ5_CLOSY
Unannotated protein.
   
  0.897
metAA
Unannotated protein; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family.
    
  0.896
E7GKA1_CLOSY
Unannotated protein.
  
 0.883
E7GUG0_CLOSY
Unannotated protein.
  
 0.883
Your Current Organism:
Clostridium symbiosum
NCBI taxonomy Id: 1512
Other names: ATCC 14940, Bacteroides symbiosus, DSM 934, [. symbiosum, [Clostridium] symbiosum
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.