STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TOP1DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (964 aa)    
Predicted Functional Partners:
spp27
Upstream activation factor subunit spp27.
    
 
 0.928
EVAR_64577_1
Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.
    
 
 0.925
ube2ia
SUMO-conjugating enzyme UBC9-A; Belongs to the ubiquitin-conjugating enzyme family.
    
 0.919
gkt
Probable tyrosyl-DNA phosphodiesterase.
    
 
 0.916
gkt-2
Probable tyrosyl-DNA phosphodiesterase.
    
 
 0.916
PIAS4
E3 SUMO-protein ligase PIAS4.
   
 
 0.916
Top2
DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.
   
 
 0.914
TOP2
DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.
   
 
 0.914
Recql4
ATP-dependent DNA helicase Q4.
   
 
 0.914
Blm
Bloom syndrome protein homolog.
    
 
 0.913
Your Current Organism:
Eumeta japonica
NCBI taxonomy Id: 151549
Other names: E. japonica
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