node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Blm | EVAR_64577_1 | A0A4C1X728 | A0A4C1ZGY1 | Bloom syndrome protein homolog. | Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | 0.813 |
Blm | PIAS4 | A0A4C1X728 | A0A4C1Y3H2 | Bloom syndrome protein homolog. | E3 SUMO-protein ligase PIAS4. | 0.529 |
Blm | TOP1 | A0A4C1X728 | A0A4C1XFV1 | Bloom syndrome protein homolog. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | 0.913 |
Blm | TOP2 | A0A4C1X728 | A0A4C1U0F0 | Bloom syndrome protein homolog. | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. | 0.549 |
Blm | Top2 | A0A4C1X728 | A0A4C1SII2 | Bloom syndrome protein homolog. | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. | 0.549 |
Blm | ube2ia | A0A4C1X728 | A0A4C1XNW7 | Bloom syndrome protein homolog. | SUMO-conjugating enzyme UBC9-A; Belongs to the ubiquitin-conjugating enzyme family. | 0.852 |
EVAR_64577_1 | Blm | A0A4C1ZGY1 | A0A4C1X728 | Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | Bloom syndrome protein homolog. | 0.813 |
EVAR_64577_1 | Recql4 | A0A4C1ZGY1 | A0A4C1U0J5 | Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | ATP-dependent DNA helicase Q4. | 0.837 |
EVAR_64577_1 | TOP1 | A0A4C1ZGY1 | A0A4C1XFV1 | Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | 0.925 |
EVAR_64577_1 | TOP2 | A0A4C1ZGY1 | A0A4C1U0F0 | Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. | 0.456 |
EVAR_64577_1 | Top2 | A0A4C1ZGY1 | A0A4C1SII2 | Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. | 0.456 |
PIAS4 | Blm | A0A4C1Y3H2 | A0A4C1X728 | E3 SUMO-protein ligase PIAS4. | Bloom syndrome protein homolog. | 0.529 |
PIAS4 | Recql4 | A0A4C1Y3H2 | A0A4C1U0J5 | E3 SUMO-protein ligase PIAS4. | ATP-dependent DNA helicase Q4. | 0.539 |
PIAS4 | TOP1 | A0A4C1Y3H2 | A0A4C1XFV1 | E3 SUMO-protein ligase PIAS4. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | 0.916 |
PIAS4 | TOP2 | A0A4C1Y3H2 | A0A4C1U0F0 | E3 SUMO-protein ligase PIAS4. | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. | 0.727 |
PIAS4 | Top2 | A0A4C1Y3H2 | A0A4C1SII2 | E3 SUMO-protein ligase PIAS4. | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. | 0.727 |
PIAS4 | ube2ia | A0A4C1Y3H2 | A0A4C1XNW7 | E3 SUMO-protein ligase PIAS4. | SUMO-conjugating enzyme UBC9-A; Belongs to the ubiquitin-conjugating enzyme family. | 0.996 |
Recql4 | EVAR_64577_1 | A0A4C1U0J5 | A0A4C1ZGY1 | ATP-dependent DNA helicase Q4. | Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | 0.837 |
Recql4 | PIAS4 | A0A4C1U0J5 | A0A4C1Y3H2 | ATP-dependent DNA helicase Q4. | E3 SUMO-protein ligase PIAS4. | 0.539 |
Recql4 | TOP1 | A0A4C1U0J5 | A0A4C1XFV1 | ATP-dependent DNA helicase Q4. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | 0.914 |