node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SFU42033.1 | SFU42926.1 | SAMN02910342_00426 | SAMN02910342_00471 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Chorismate mutase / prephenate dehydratase. | 0.523 |
SFU42033.1 | SFU55030.1 | SAMN02910342_00426 | SAMN02910342_00893 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Cystathionine gamma-synthase. | 0.992 |
SFU42033.1 | SFU95435.1 | SAMN02910342_00426 | SAMN02910342_02579 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Pyruvate-ferredoxin/flavodoxin oxidoreductase. | 0.984 |
SFU42033.1 | SFV02477.1 | SAMN02910342_00426 | SAMN02910342_03039 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Methylenetetrahydrofolate reductase (NADPH); Belongs to the methylenetetrahydrofolate reductase family. | 0.999 |
SFU42033.1 | folD | SAMN02910342_00426 | SAMN02910342_00636 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.950 |
SFU42033.1 | glyA | SAMN02910342_00426 | SAMN02910342_03188 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.960 |
SFU42033.1 | metAA | SAMN02910342_00426 | SAMN02910342_00318 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. | 0.903 |
SFU42033.1 | metE | SAMN02910342_00426 | SAMN02910342_03040 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Methionine synthase (B12-independent); Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.992 |
SFU42033.1 | metG | SAMN02910342_00426 | SAMN02910342_01559 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.954 |
SFU42033.1 | metK | SAMN02910342_00426 | SAMN02910342_02189 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.976 |
SFU42926.1 | SFU42033.1 | SAMN02910342_00471 | SAMN02910342_00426 | Chorismate mutase / prephenate dehydratase. | 5-methyltetrahydrofolate--homocysteine methyltransferase. | 0.523 |
SFU42926.1 | SFU55030.1 | SAMN02910342_00471 | SAMN02910342_00893 | Chorismate mutase / prephenate dehydratase. | Cystathionine gamma-synthase. | 0.651 |
SFU42926.1 | SFU95435.1 | SAMN02910342_00471 | SAMN02910342_02579 | Chorismate mutase / prephenate dehydratase. | Pyruvate-ferredoxin/flavodoxin oxidoreductase. | 0.930 |
SFU42926.1 | SFV02477.1 | SAMN02910342_00471 | SAMN02910342_03039 | Chorismate mutase / prephenate dehydratase. | Methylenetetrahydrofolate reductase (NADPH); Belongs to the methylenetetrahydrofolate reductase family. | 0.823 |
SFU42926.1 | folD | SAMN02910342_00471 | SAMN02910342_00636 | Chorismate mutase / prephenate dehydratase. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.496 |
SFU42926.1 | glyA | SAMN02910342_00471 | SAMN02910342_03188 | Chorismate mutase / prephenate dehydratase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.537 |
SFU42926.1 | metE | SAMN02910342_00471 | SAMN02910342_03040 | Chorismate mutase / prephenate dehydratase. | Methionine synthase (B12-independent); Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.644 |
SFU42926.1 | metG | SAMN02910342_00471 | SAMN02910342_01559 | Chorismate mutase / prephenate dehydratase. | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.478 |
SFU42926.1 | metK | SAMN02910342_00471 | SAMN02910342_02189 | Chorismate mutase / prephenate dehydratase. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.423 |
SFU55030.1 | SFU42033.1 | SAMN02910342_00893 | SAMN02910342_00426 | Cystathionine gamma-synthase. | 5-methyltetrahydrofolate--homocysteine methyltransferase. | 0.992 |