node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APR06524.1 | dltA | FAM21731_00303 | FAM21731_00885 | Cyclopentanol dehydrogenase. | D-alanine--poly(phosphoribitol) ligase subunit 1; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs to [...] | 0.901 |
APR06769.1 | dltA | FAM21731_00556 | FAM21731_00885 | Putative oxidoreductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | D-alanine--poly(phosphoribitol) ligase subunit 1; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs to [...] | 0.903 |
APR06769.1 | menE | FAM21731_00556 | FAM21731_00657 | Putative oxidoreductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 2-succinylbenzoate--CoA ligase; Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl-CoA (OSB-CoA); Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily. | 0.412 |
APR07086.1 | APR07088.1 | FAM21731_00882 | FAM21731_00884 | Hypothetical protein; DltD C-terminal region. | Peptidoglycan O-acetyltransferase; Could be involved in the transport of activated D-alanine through the membrane. | 0.999 |
APR07086.1 | APR07091.1 | FAM21731_00882 | FAM21731_00887 | Hypothetical protein; DltD C-terminal region. | Putative penicillin-binding protein PbpX. | 0.975 |
APR07086.1 | dltA | FAM21731_00882 | FAM21731_00885 | Hypothetical protein; DltD C-terminal region. | D-alanine--poly(phosphoribitol) ligase subunit 1; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs to [...] | 0.995 |
APR07086.1 | dltC | FAM21731_00882 | FAM21731_00883 | Hypothetical protein; DltD C-terminal region. | D-alanine--poly(phosphoribitol) ligase subunit 2; Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC- carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. | 0.999 |
APR07088.1 | APR07086.1 | FAM21731_00884 | FAM21731_00882 | Peptidoglycan O-acetyltransferase; Could be involved in the transport of activated D-alanine through the membrane. | Hypothetical protein; DltD C-terminal region. | 0.999 |
APR07088.1 | APR07091.1 | FAM21731_00884 | FAM21731_00887 | Peptidoglycan O-acetyltransferase; Could be involved in the transport of activated D-alanine through the membrane. | Putative penicillin-binding protein PbpX. | 0.958 |
APR07088.1 | dltA | FAM21731_00884 | FAM21731_00885 | Peptidoglycan O-acetyltransferase; Could be involved in the transport of activated D-alanine through the membrane. | D-alanine--poly(phosphoribitol) ligase subunit 1; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs to [...] | 0.999 |
APR07088.1 | dltC | FAM21731_00884 | FAM21731_00883 | Peptidoglycan O-acetyltransferase; Could be involved in the transport of activated D-alanine through the membrane. | D-alanine--poly(phosphoribitol) ligase subunit 2; Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC- carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. | 0.999 |
APR07091.1 | APR07086.1 | FAM21731_00887 | FAM21731_00882 | Putative penicillin-binding protein PbpX. | Hypothetical protein; DltD C-terminal region. | 0.975 |
APR07091.1 | APR07088.1 | FAM21731_00887 | FAM21731_00884 | Putative penicillin-binding protein PbpX. | Peptidoglycan O-acetyltransferase; Could be involved in the transport of activated D-alanine through the membrane. | 0.958 |
APR07091.1 | dltA | FAM21731_00887 | FAM21731_00885 | Putative penicillin-binding protein PbpX. | D-alanine--poly(phosphoribitol) ligase subunit 1; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs to [...] | 0.950 |
APR07091.1 | dltC | FAM21731_00887 | FAM21731_00883 | Putative penicillin-binding protein PbpX. | D-alanine--poly(phosphoribitol) ligase subunit 2; Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC- carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. | 0.861 |
APR07667.1 | dltA | FAM21731_01490 | FAM21731_00885 | Putative oxidoreductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | D-alanine--poly(phosphoribitol) ligase subunit 1; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs to [...] | 0.903 |
APR08017.1 | ddl | FAM21731_01862 | FAM21731_00008 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | D-alanine--D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | 0.957 |
APR08017.1 | dltA | FAM21731_01862 | FAM21731_00885 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | D-alanine--poly(phosphoribitol) ligase subunit 1; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs to [...] | 0.928 |
APR08017.1 | dltC | FAM21731_01862 | FAM21731_00883 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | D-alanine--poly(phosphoribitol) ligase subunit 2; Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC- carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. | 0.903 |
ddl | APR08017.1 | FAM21731_00008 | FAM21731_01862 | D-alanine--D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | 0.957 |