STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
APR08653.1Non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (199 aa)    
Predicted Functional Partners:
folE
GTP cyclohydrolase 1.
  
  
 0.985
murI
Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis.
    0.984
APR08652.1
Phosphodiesterase.
 
  
 0.982
guaA
GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP.
 
 
 0.957
APR06579.1
Inosine-5'-monophosphate dehydrogenase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
  
 0.922
xpt
Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
   
 0.914
APR07759.1
Diadenosine hexaphosphate hydrolase.
  
 
 0.909
APR08029.1
Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
  
 
 0.907
APR07082.1
Hypothetical protein.
 
    0.784
APR08651.1
CBS domain-containing protein YkuL.
       0.744
Your Current Organism:
Lactobacillus parabuchneri
NCBI taxonomy Id: 152331
Other names: ATCC 49374, CCUG 32261, CIP 103368, CIP 106749 [[Lactobacillus ferintoshensis Simpson et al. 2002]], DSM 5707, JCM 12493, JCM 12511 [[Lactobacillus ferintoshensis Simpson et al. 2002]], L. parabuchneri, LMG 11457, LMG:11457, Lactobacillus ferintoshensis, Lactobacillus ferintoshensis Simpson et al. 2002, NBRC 107865, NCDO 2748, NCIMB 8838, strain R7-84 [[Lactobacillus ferintoshensis Simpson et al. 2002]], strain R7-84(T) [[Lactobacillus ferintoshensis Simpson et al. 2002]]
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