STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lysKlysine--tRNA ligase; Class I; LysRS1; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri this enzyme charges both tRNA molecules for lysine that exist in this organism (but the tRNALysUUU very poorly) and in the presence of LysRS2 can charge tRNAPyl with lysine; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-I aminoacyl-tRNA synthetase family. (526 aa)    
Predicted Functional Partners:
IP70_01690
Cytoplasmic protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
    0.764
IP70_00700
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.670
IP70_06880
Hypothetical protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
  
     0.602
rpsD
30S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
  
    0.578
nusG
Antitermination protein NusG; Participates in transcription elongation, termination and antitermination.
   
    0.572
nadK
Inorganic polyphosphate kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
  
     0.561
IP70_08010
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
  0.543
IP70_20915
lysyl-tRNA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
  0.543
IP70_11660
Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.
       0.519
rplS
50S ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
   
    0.513
Your Current Organism:
alpha proteobacterium AAP38
NCBI taxonomy Id: 1523418
Other names: a. proteobacterium AAP38
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