SFN86424.1 protein (Anaerocolumna aminovalerica)

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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Score

SFN86424.1

Hypothetical protein. (272 aa)

Predicted Functional Partners:

SFO36719.1

0.770

SFN86405.1

0.676

SFN77806.1

0.535

SFN86568.1

0.491

SFO00282.1

0.470

SFO43015.1

0.456

SFO63957.1

0.445

SFO11355.1

0.441

SFO67589.1

0.433

SFN86392.1

0.404

Your Current Organism:

Anaerocolumna aminovalerica

NCBI taxonomy Id: 1527
Other names: A. aminovalerica, ATCC 13725, CIP 104304, Clostridium aminovalericum, JCM 11016

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SFN77806.1	SFN86424.1	SAMN04489757_101196	SAMN04489757_10366	Fructokinase.	Hypothetical protein.	0.535
SFN77806.1	SFO11355.1	SAMN04489757_101196	SAMN04489757_10988	Fructokinase.	PTS system IIA component, Glc family.	0.989
SFN77806.1	SFO36719.1	SAMN04489757_101196	SAMN04489757_12054	Fructokinase.	Hypothetical protein.	0.467
SFN77806.1	SFO63957.1	SAMN04489757_101196	SAMN04489757_1535	Fructokinase.	PTS system, glucose subfamily, IIA component.	0.989
SFN77806.1	SFO67589.1	SAMN04489757_101196	SAMN04489757_1669	Fructokinase.	PTS system, glucose subfamily, IIA component.	0.989
SFN86392.1	SFN86405.1	SAMN04489757_10363	SAMN04489757_10365	NhaP-type Na+/H+ or K+/H+ antiporter.	Fucose permease.	0.441
SFN86392.1	SFN86424.1	SAMN04489757_10363	SAMN04489757_10366	NhaP-type Na+/H+ or K+/H+ antiporter.	Hypothetical protein.	0.404
SFN86405.1	SFN86392.1	SAMN04489757_10365	SAMN04489757_10363	Fucose permease.	NhaP-type Na+/H+ or K+/H+ antiporter.	0.441
SFN86405.1	SFN86424.1	SAMN04489757_10365	SAMN04489757_10366	Fucose permease.	Hypothetical protein.	0.676
SFN86424.1	SFN77806.1	SAMN04489757_10366	SAMN04489757_101196	Hypothetical protein.	Fructokinase.	0.535
SFN86424.1	SFN86392.1	SAMN04489757_10366	SAMN04489757_10363	Hypothetical protein.	NhaP-type Na+/H+ or K+/H+ antiporter.	0.404
SFN86424.1	SFN86405.1	SAMN04489757_10366	SAMN04489757_10365	Hypothetical protein.	Fucose permease.	0.676
SFN86424.1	SFN86568.1	SAMN04489757_10366	SAMN04489757_10375	Hypothetical protein.	23S rRNA pseudouridine1911/1915/1917 synthase; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family.	0.491
SFN86424.1	SFO00282.1	SAMN04489757_10366	SAMN04489757_10685	Hypothetical protein.	CBS domain-containing protein.	0.470
SFN86424.1	SFO11355.1	SAMN04489757_10366	SAMN04489757_10988	Hypothetical protein.	PTS system IIA component, Glc family.	0.441
SFN86424.1	SFO36719.1	SAMN04489757_10366	SAMN04489757_12054	Hypothetical protein.	Hypothetical protein.	0.770
SFN86424.1	SFO43015.1	SAMN04489757_10366	SAMN04489757_12551	Hypothetical protein.	Riboflavin kinase / FMN adenylyltransferase; Belongs to the ribF family.	0.456
SFN86424.1	SFO63957.1	SAMN04489757_10366	SAMN04489757_1535	Hypothetical protein.	PTS system, glucose subfamily, IIA component.	0.445
SFN86424.1	SFO67589.1	SAMN04489757_10366	SAMN04489757_1669	Hypothetical protein.	PTS system, glucose subfamily, IIA component.	0.433
SFN86568.1	SFN86424.1	SAMN04489757_10375	SAMN04489757_10366	23S rRNA pseudouridine1911/1915/1917 synthase; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family.	Hypothetical protein.	0.491

page 1 of 3

Network Stats

number of nodes:

2

number of edges:

1

average node degree:

1

avg. local clustering coefficient:

1

expected number of edges:

1

PPI enrichment p-value:

0.5

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009252

Peptidoglycan biosynthetic process

8 of 34

2.03

4.81

2.24e-12

GO:0008360

Regulation of cell shape

8 of 49

1.88

4.25

3.90e-12

GO:0071555

Cell wall organization

8 of 59

1.79

3.91

8.16e-12

GO:0051301

Cell division

8 of 66

1.75

3.69

1.56e-11

GO:0007049

Cell cycle

7 of 63

1.71

3.15

1.41e-09

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016881

Acid-amino acid ligase activity

5 of 17

2.13

3.14

3.12e-07

GO:0047480

UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity

2 of 2

2.66

1.28

0.0047

GO:0008766

UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity

2 of 2

2.66

1.28

0.0047

GO:0043168

Anion binding

7 of 794

0.61

0.36

0.0471

GO:0043167

Ion binding

9 of 1444

0.46

0.29

0.0471

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:25309529

(2014) L,L-diaminopimelate aminotransferase (DapL): a putative target for the development of narrow-spectrum antibacterial compounds.

2 of 4

2.36

1.07

0.0105

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1162

Cell shape

8 of 15

2.39

6.72

4.58e-15

CL:1164

Cell shape

7 of 10

2.51

6.47

7.15e-14

CL:1157

Mixed, incl. Cell shape, and Cell division site

9 of 33

2.1

5.82

4.58e-15

CL:1166

MurE/MurF, N-terminal, and UDP-glycosyltransferase activity

5 of 5

2.66

4.92

3.97e-10

CL:1638

Lysine biosynthesis

2 of 5

2.26

1.13

0.0079

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

dsy00550

Peptidoglycan biosynthesis

8 of 29

2.1

5.5

6.05e-14

dsy00300

Lysine biosynthesis

5 of 22

2.02

3.27

6.80e-08

dsy01502

Vancomycin resistance

4 of 14

2.12

2.92

9.39e-07

dsy00471

D-Glutamine and D-glutamate metabolism

2 of 3

2.49

1.65

0.00089

dsy01100

Metabolic pathways

10 of 692

0.82

0.85

8.17e-07

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0573

Peptidoglycan synthesis

8 of 19

2.29

6.37

6.93e-15

KW-0961

Cell wall biogenesis/degradation

8 of 23

2.2

6.09

9.12e-15

KW-0132

Cell division

7 of 31

2.02

4.53

1.23e-11

KW-0131

Cell cycle

7 of 31

2.02

4.53

1.23e-11

KW-0436

Ligase

5 of 73

1.5

1.84

9.57e-06

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02875

Mur ligase family, glutamate ligase domain

5 of 7

2.52

4.14

9.63e-09

PF08245

Mur ligase middle domain

5 of 9

2.41

4.01

1.21e-08

PF01225

Mur ligase family, catalytic domain

4 of 4

2.66

3.56

2.06e-07

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036615

Mur ligase, C-terminal domain superfamily

5 of 7

2.52

3.95

2.40e-08

IPR004101

Mur ligase, C-terminal

5 of 7

2.52

3.95

2.40e-08

IPR036565

Mur-like, catalytic domain superfamily

5 of 9

2.41

3.87

2.40e-08

IPR013221

Mur ligase, central

5 of 9

2.41

3.87

2.40e-08

IPR000713

Mur ligase, N-terminal catalytic domain

4 of 4

2.66

3.47

3.08e-07

(more ...)

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