SFO32623.1 protein (Anaerocolumna aminovalerica)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

SFO32623.1

Type IV leader peptidase family protein. (184 aa)

Predicted Functional Partners:

SFO32579.1

0.944

SFO32595.1

0.886

SFO32561.1

0.825

SFO34268.1

0.750

SFO32608.1

0.694

SFO32502.1

0.584

SFO32468.1

0.579

SFO32517.1

0.550

SFO14064.1

0.511

SFO34326.1

0.491

Your Current Organism:

Anaerocolumna aminovalerica

NCBI taxonomy Id: 1527
Other names: A. aminovalerica, ATCC 13725, CIP 104304, Clostridium aminovalericum, JCM 11016

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SFO14064.1	SFO32623.1	SAMN04489757_110104	SAMN04489757_11828	Nitroreductase.	Type IV leader peptidase family protein.	0.511
SFO32468.1	SFO32502.1	SAMN04489757_11818	SAMN04489757_11820	FHA domain-containing protein.	Leader peptidase (prepilin peptidase) / N-methyltransferase.	0.900
SFO32468.1	SFO32517.1	SAMN04489757_11818	SAMN04489757_11821	FHA domain-containing protein.	Hypothetical protein.	0.869
SFO32468.1	SFO32561.1	SAMN04489757_11818	SAMN04489757_11824	FHA domain-containing protein.	Hypothetical protein.	0.798
SFO32468.1	SFO32579.1	SAMN04489757_11818	SAMN04489757_11825	FHA domain-containing protein.	Tight adherence protein B.	0.708
SFO32468.1	SFO32595.1	SAMN04489757_11818	SAMN04489757_11826	FHA domain-containing protein.	Pilus assembly protein CpaF.	0.605
SFO32468.1	SFO32608.1	SAMN04489757_11818	SAMN04489757_11827	FHA domain-containing protein.	Hypothetical protein.	0.784
SFO32468.1	SFO32623.1	SAMN04489757_11818	SAMN04489757_11828	FHA domain-containing protein.	Type IV leader peptidase family protein.	0.579
SFO32468.1	SFO34326.1	SAMN04489757_11818	SAMN04489757_11917	FHA domain-containing protein.	Pilus assembly protein CpaF.	0.446
SFO32502.1	SFO32468.1	SAMN04489757_11820	SAMN04489757_11818	Leader peptidase (prepilin peptidase) / N-methyltransferase.	FHA domain-containing protein.	0.900
SFO32502.1	SFO32517.1	SAMN04489757_11820	SAMN04489757_11821	Leader peptidase (prepilin peptidase) / N-methyltransferase.	Hypothetical protein.	0.906
SFO32502.1	SFO32561.1	SAMN04489757_11820	SAMN04489757_11824	Leader peptidase (prepilin peptidase) / N-methyltransferase.	Hypothetical protein.	0.872
SFO32502.1	SFO32579.1	SAMN04489757_11820	SAMN04489757_11825	Leader peptidase (prepilin peptidase) / N-methyltransferase.	Tight adherence protein B.	0.758
SFO32502.1	SFO32608.1	SAMN04489757_11820	SAMN04489757_11827	Leader peptidase (prepilin peptidase) / N-methyltransferase.	Hypothetical protein.	0.585
SFO32502.1	SFO32623.1	SAMN04489757_11820	SAMN04489757_11828	Leader peptidase (prepilin peptidase) / N-methyltransferase.	Type IV leader peptidase family protein.	0.584
SFO32502.1	SFO34268.1	SAMN04489757_11820	SAMN04489757_11914	Leader peptidase (prepilin peptidase) / N-methyltransferase.	Hypothetical protein.	0.750
SFO32517.1	SFO32468.1	SAMN04489757_11821	SAMN04489757_11818	Hypothetical protein.	FHA domain-containing protein.	0.869
SFO32517.1	SFO32502.1	SAMN04489757_11821	SAMN04489757_11820	Hypothetical protein.	Leader peptidase (prepilin peptidase) / N-methyltransferase.	0.906
SFO32517.1	SFO32561.1	SAMN04489757_11821	SAMN04489757_11824	Hypothetical protein.	Hypothetical protein.	0.958
SFO32517.1	SFO32579.1	SAMN04489757_11821	SAMN04489757_11825	Hypothetical protein.	Tight adherence protein B.	0.915

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

41

average node degree:

7.45

avg. local clustering coefficient:

0.924

expected number of edges:

14

PPI enrichment p-value:

4.8e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

11 of 188

1.3

2.17

1.56e-11

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

11 of 85

1.65

3.94

1.42e-15

GO:0019843

rRNA binding

3 of 28

1.56

0.8

0.0228

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005840

Ribosome

11 of 96

1.59

3.65

3.29e-15

GO:0044391

Ribosomal subunit

6 of 71

1.46

1.88

3.62e-06

GO:0015934

Large ribosomal subunit

4 of 40

1.53

1.38

0.00057

GO:0005761

Mitochondrial ribosome

3 of 26

1.6

1.07

0.0053

GO:0005762

Mitochondrial large ribosomal subunit

2 of 13

1.72

0.71

0.0410

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2525

Structural constituent of ribosome

10 of 16

2.33

8.2

1.05e-19

CL:2522

Organellar ribosome, and SRP-dependent cotranslational protein targeting to membrane

11 of 34

2.04

6.77

1.05e-19

CL:2527

Mixed, incl. L28p-like, and Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like

5 of 5

2.53

4.62

1.01e-09

CL:2541

SRP-dependent cotranslational protein targeting to membrane

4 of 8

2.23

3.01

9.67e-07

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03010

Ribosome

11 of 93

1.61

3.81

5.20e-16

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-72766

Translation

10 of 157

1.34

2.2

1.75e-10

MAP-72706

GTP hydrolysis and joining of the 60S ribosomal subunit

6 of 62

1.52

1.95

4.37e-06

MAP-72689

Formation of a pool of free 40S subunits

6 of 65

1.5

1.92

4.37e-06

MAP-975956

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

6 of 67

1.49

1.9

4.37e-06

MAP-1799339

SRP-dependent cotranslational protein targeting to membrane

6 of 67

1.49

1.9

4.37e-06

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0044391

Ribosomal subunit

7 of 74

1.51

2.19

3.06e-07

GOCC:0022626

Cytosolic ribosome

5 of 54

1.5

1.68

4.13e-05

GOCC:0015934

Large ribosomal subunit

4 of 43

1.5

1.37

0.00050

GOCC:0015935

Small ribosomal subunit

3 of 30

1.53

1.03

0.0058

GOCC:0022625

Cytosolic large ribosomal subunit

3 of 31

1.52

1.02

0.0058

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

5 of 63

1.43

1.48

0.00012

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