STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Hgd2-hydroxymethylglutarate dehydrogenase; Catalyzes the conversion of 2-formylglutarate to (S)-2- hydroxymethylglutarate. Has very low activity with (S)-3- hydroxyisobutyrate. (301 aa)    
Predicted Functional Partners:
SDX29925.1
Uncharacterized conserved protein YgbK, DUF1537 family.
  
 0.940
Ena
Enamidase; Decyclization of 6-oxo-1,4,5,6-tetrahydronicotinate to form 2-(enamine)glutarate, followed by hydrolysis to form (S)-2- formylglutarate; Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.
 
  
  0.829
SDX31168.1
Pyruvate-ferredoxin/flavodoxin oxidoreductase.
    
  0.816
SDY18162.1
Pyruvate-ferredoxin/flavodoxin oxidoreductase.
    
  0.816
SDX96002.1
Hypothetical protein; Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.
 
     0.778
ndhM
Molybdopterin-binding domain of aldehyde dehydrogenase; Catalyzes the hydroxylation of nicotinate to 6- hydroxynicotinate. Also active against 2-pyrazinecarboxylic acid, but inactive against other nicotinate analogs.
  
    0.776
ndhL
Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Catalyzes the hydroxylation of nicotinate to 6- hydroxynicotinate. Also active against 2-pyrazinecarboxylic acid, but inactive against other nicotinate analogs.
  
    0.776
ndhF
Purine hydroxylase gamma subunit apoprotein; Catalyzes the hydroxylation of nicotinate to 6- hydroxynicotinate. Also active against 2-pyrazinecarboxylic acid, but inactive against other nicotinate analogs.
    
  0.776
ndhS
Purine hydroxylase delta subunit apoprotein; Catalyzes the hydroxylation of nicotinate to 6- hydroxynicotinate. Also active against 2-pyrazinecarboxylic acid, but inactive against other nicotinate analogs.
  
    0.775
Hnr
NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit; Catalyzes the reversible reduction of 6-hydroxynicotinate to 6-oxo-1,4,5,6-tetrahydronicotinate.
 
     0.763
Your Current Organism:
Eubacterium barkeri
NCBI taxonomy Id: 1528
Other names: ATCC 25849, CIP 104307, Clostridium barkeri, E. barkeri, Inflabilis barati, VPI 5359
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.