MYP_1452 protein (Sporocytophaga myxococcoides)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

MYP_1452

2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase. (161 aa)

Predicted Functional Partners:

MYP_1369

0.999

folE

0.995

folE-2

0.995

MYP_29

0.994

MYP_771

0.982

MYP_401

0.901

ribBA

0.898

MYP_533

0.833

MYP_33

0.823

MYP_3774

0.672

Your Current Organism:

Sporocytophaga myxococcoides

NCBI taxonomy Id: 153721
Other names: ATCC 10010, Cytophaga myxococcoides, DSM 11118, LMG 8393, LMG:8393, S. myxococcoides, Spirochaeta cytophaga

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MYP_1369	MYP_1452	MYP_1369	MYP_1452	Hypothetical protein.	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase.	0.999
MYP_1369	MYP_29	MYP_1369	MYP_29	Hypothetical protein.	Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin.	0.987
MYP_1369	MYP_3774	MYP_1369	MYP_3774	Hypothetical protein.	Para-aminobenzoate synthase, aminase component.	0.696
MYP_1369	MYP_401	MYP_1369	MYP_401	Hypothetical protein.	Hypothetical protein.	0.898
MYP_1369	MYP_771	MYP_1369	MYP_771	Hypothetical protein.	Tetrahydrofolate synthase; Belongs to the folylpolyglutamate synthase family.	0.998
MYP_1369	folE	MYP_1369	MYP_2303	Hypothetical protein.	GTP cyclohydrolase I.	0.982
MYP_1369	folE-2	MYP_1369	MYP_3271	Hypothetical protein.	GTP cyclohydrolase.	0.974
MYP_1452	MYP_1369	MYP_1452	MYP_1369	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase.	Hypothetical protein.	0.999
MYP_1452	MYP_29	MYP_1452	MYP_29	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase.	Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin.	0.994
MYP_1452	MYP_33	MYP_1452	MYP_33	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase.	Hypothetical protein.	0.823
MYP_1452	MYP_3774	MYP_1452	MYP_3774	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase.	Para-aminobenzoate synthase, aminase component.	0.672
MYP_1452	MYP_401	MYP_1452	MYP_401	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase.	Hypothetical protein.	0.901
MYP_1452	MYP_533	MYP_1452	MYP_533	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase.	Hypothetical protein; Belongs to the GTP cyclohydrolase I type 2/NIF3 family.	0.833
MYP_1452	MYP_771	MYP_1452	MYP_771	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase.	Tetrahydrofolate synthase; Belongs to the folylpolyglutamate synthase family.	0.982
MYP_1452	folE	MYP_1452	MYP_2303	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase.	GTP cyclohydrolase I.	0.995
MYP_1452	folE-2	MYP_1452	MYP_3271	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase.	GTP cyclohydrolase.	0.995
MYP_1452	ribBA	MYP_1452	MYP_2359	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase.	3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.	0.898
MYP_29	MYP_1369	MYP_29	MYP_1369	Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin.	Hypothetical protein.	0.987
MYP_29	MYP_1452	MYP_29	MYP_1452	Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin.	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase.	0.994
MYP_29	MYP_401	MYP_29	MYP_401	Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin.	Hypothetical protein.	0.449

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

44

average node degree:

8

avg. local clustering coefficient:

0.838

expected number of edges:

12

PPI enrichment p-value:

1.85e-12

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007264

Small GTPase mediated signal transduction

7 of 23

2.13

4.42

1.48e-10

GO:0007163

Establishment or maintenance of cell polarity

5 of 26

1.93

2.64

1.60e-06

GO:0022604

Regulation of cell morphogenesis

4 of 15

2.07

2.3

2.18e-05

GO:0030036

Actin cytoskeleton organization

5 of 49

1.65

1.94

2.18e-05

GO:0007165

Signal transduction

8 of 166

1.33

1.78

4.94e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003924

GTPase activity

9 of 77

1.71

3.64

6.94e-12

GO:0005525

GTP binding

9 of 94

1.62

3.26

1.88e-11

GO:0019901

Protein kinase binding

3 of 24

1.74

1.36

0.0014

GO:0005509

Calcium ion binding

2 of 19

1.67

0.69

0.0438

GO:0043167

Ion binding

11 of 1226

0.6

0.53

2.75e-05

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042995

Cell projection

4 of 31

1.75

1.73

0.00017

GO:0005886

Plasma membrane

8 of 186

1.28

1.67

6.01e-07

GO:0005938

Cell cortex

4 of 78

1.35

0.99

0.0041

GO:0005856

Cytoskeleton

4 of 150

1.07

0.59

0.0320

GO:0016020

Membrane

9 of 1063

0.57

0.42

0.0062

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3834

Pleckstrin homology domain 5, and Small GTPase Rho

4 of 8

2.34

2.98

1.59e-06

CL:3831

Mixed, incl. Small GTPase mediated signal transduction, and Pleckstrin homology domain 5

5 of 22

2.0

2.85

7.39e-07

CL:3778

MAPK signaling pathway - yeast, and Small GTPase mediated signal transduction

6 of 50

1.72

2.48

7.21e-07

CL:4512

COPI vesicle coat, and ARF-like small GTPases

2 of 12

1.86

0.72

0.0421

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

wic04144

Endocytosis

4 of 59

1.47

1.27

0.00090

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9012999

RHO GTPase cycle

8 of 99

1.55

2.66

2.94e-09

MAP-9716542

Signaling by Rho GTPases, Miro GTPases and RHOBTB3

9 of 140

1.45

2.47

8.73e-10

MAP-194315

Signaling by Rho GTPases

8 of 136

1.41

2.17

2.21e-08

MAP-9696273

RND1 GTPase cycle

3 of 9

2.17

1.8

0.00033

MAP-9696270

RND2 GTPase cycle

2 of 2

2.64

1.31

0.0041

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0342

GTP-binding

8 of 42

1.92

4.45

2.50e-12

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR005225

Small GTP-binding protein domain

8 of 38

1.97

4.4

1.11e-11

IPR001806

Small GTPase

6 of 21

2.1

3.74

7.40e-09

IPR003578

Small GTPase Rho

4 of 4

2.64

3.36

4.95e-07

IPR027417

P-loop containing nucleoside triphosphate hydrolase

9 of 295

1.13

1.39

4.35e-07

IPR024156

Small GTPase superfamily, ARF type

2 of 4

2.34

0.85

0.0277

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00174

Rho (Ras homology) subfamily of Ras-like small GTPases

5 of 5

2.64

4.65

1.28e-09

SM00177

ARF-like small GTPases

2 of 4

2.34

1.12

0.0086

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (22%) [HD]

Permalink

Network

Neighborhood

Experiments

Fusion

Databases

Cooccurrence

Textmining

Coexpression

© STRING Consortium 2024

Credits

Access

Info

About