node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
guaA | hisA | MYP_2321 | MYP_1790 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.918 |
guaA | hisB | MYP_2321 | MYP_595 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Imidazoleglycerol-phosphate dehydratase; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | 0.530 |
guaA | hisF | MYP_2321 | MYP_598 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Imidazole glycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.546 |
guaA | hisH | MYP_2321 | MYP_596 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.565 |
hisA | guaA | MYP_1790 | MYP_2321 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.918 |
hisA | hisB | MYP_1790 | MYP_595 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazoleglycerol-phosphate dehydratase; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | 0.988 |
hisA | hisC | MYP_1790 | MYP_594 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Histidinol phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.945 |
hisA | hisD | MYP_1790 | MYP_586 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.980 |
hisA | hisF | MYP_1790 | MYP_598 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazole glycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.995 |
hisA | hisG | MYP_1790 | MYP_585 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.979 |
hisA | hisH | MYP_1790 | MYP_596 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.992 |
hisA | hisI | MYP_1790 | MYP_599 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; In the N-terminal section; belongs to the PRA-CH family. | 0.999 |
hisA | trpC | MYP_1790 | MYP_1786 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Indole-3-glycerol-phosphate synthase; Belongs to the TrpC family. | 0.831 |
hisA | trpF | MYP_1790 | MYP_1787 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Hypothetical protein; Belongs to the TrpF family. | 0.825 |
hisB | guaA | MYP_595 | MYP_2321 | Imidazoleglycerol-phosphate dehydratase; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.530 |
hisB | hisA | MYP_595 | MYP_1790 | Imidazoleglycerol-phosphate dehydratase; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.988 |
hisB | hisC | MYP_595 | MYP_594 | Imidazoleglycerol-phosphate dehydratase; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | Histidinol phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.999 |
hisB | hisD | MYP_595 | MYP_586 | Imidazoleglycerol-phosphate dehydratase; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.999 |
hisB | hisF | MYP_595 | MYP_598 | Imidazoleglycerol-phosphate dehydratase; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | Imidazole glycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisB | hisG | MYP_595 | MYP_585 | Imidazoleglycerol-phosphate dehydratase; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.993 |