msbA_4 protein (Hungatella hathewayi) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

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[Homology]

Score

msbA_4

Putative multidrug export ATP-binding/permease. (578 aa)

Predicted Functional Partners:

ecfT_5

0.942

CUO86145.1

0.934

soxS_3

0.858

ykoD_4

0.856

CUO86067.1

0.805

mntR_3

0.795

ecfT_4

0.790

ppsA

0.758

CUO06314.1

0.756

ugpC_5

0.664

Your Current Organism:

Hungatella hathewayi

NCBI taxonomy Id: 154046
Other names: CCUG 43506, Clostridium hathewayi, Clostridium hathewayi Steer et al. 2002, DSM 13479, H. hathewayi, Hungatella hathewayi (Steer et al. 2002) Kaur et al. 2014, MTCC 10951

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CUO06314.1	CUO86067.1	ERS852407_01784	ERS852407_04199	Conserved hypothetical integral membrane protein TIGR02185.	ABC transporter ATP-binding protein/permease.	0.774
CUO06314.1	ecfT_4	ERS852407_01784	ERS852407_01783	Conserved hypothetical integral membrane protein TIGR02185.	Transporter.	0.965
CUO06314.1	ecfT_5	ERS852407_01784	ERS852407_04201	Conserved hypothetical integral membrane protein TIGR02185.	Transporter.	0.806
CUO06314.1	msbA_4	ERS852407_01784	ERS852407_04198	Conserved hypothetical integral membrane protein TIGR02185.	Putative multidrug export ATP-binding/permease.	0.756
CUO06314.1	ppsA	ERS852407_01784	ERS852407_05175	Conserved hypothetical integral membrane protein TIGR02185.	Amino acid adenylation enzyme/thioester reductase family protein.	0.529
CUO06314.1	soxS_3	ERS852407_01784	ERS852407_04203	Conserved hypothetical integral membrane protein TIGR02185.	AraC family transcriptional regulator.	0.641
CUO06314.1	ykoD_4	ERS852407_01784	ERS852407_04200	Conserved hypothetical integral membrane protein TIGR02185.	Transporter.	0.788
CUO86067.1	CUO06314.1	ERS852407_04199	ERS852407_01784	ABC transporter ATP-binding protein/permease.	Conserved hypothetical integral membrane protein TIGR02185.	0.774
CUO86067.1	CUO86145.1	ERS852407_04199	ERS852407_04202	ABC transporter ATP-binding protein/permease.	Conserved hypothetical integral membrane protein TIGR02185.	0.944
CUO86067.1	ecfT_4	ERS852407_04199	ERS852407_01783	ABC transporter ATP-binding protein/permease.	Transporter.	0.818
CUO86067.1	ecfT_5	ERS852407_04199	ERS852407_04201	ABC transporter ATP-binding protein/permease.	Transporter.	0.955
CUO86067.1	mntR_3	ERS852407_04199	ERS852407_04197	ABC transporter ATP-binding protein/permease.	Mn-dependent transcriptional regulator.	0.771
CUO86067.1	msbA_4	ERS852407_04199	ERS852407_04198	ABC transporter ATP-binding protein/permease.	Putative multidrug export ATP-binding/permease.	0.805
CUO86067.1	ppsA	ERS852407_04199	ERS852407_05175	ABC transporter ATP-binding protein/permease.	Amino acid adenylation enzyme/thioester reductase family protein.	0.758
CUO86067.1	soxS_3	ERS852407_04199	ERS852407_04203	ABC transporter ATP-binding protein/permease.	AraC family transcriptional regulator.	0.871
CUO86067.1	ugpC_5	ERS852407_04199	ERS852407_01954	ABC transporter ATP-binding protein/permease.	ABC transporter ATP-binding protein; Belongs to the ABC transporter superfamily.	0.607
CUO86067.1	ykoD_4	ERS852407_04199	ERS852407_04200	ABC transporter ATP-binding protein/permease.	Transporter.	0.899
CUO86145.1	CUO86067.1	ERS852407_04202	ERS852407_04199	Conserved hypothetical integral membrane protein TIGR02185.	ABC transporter ATP-binding protein/permease.	0.944
CUO86145.1	ecfT_4	ERS852407_04202	ERS852407_01783	Conserved hypothetical integral membrane protein TIGR02185.	Transporter.	0.791
CUO86145.1	ecfT_5	ERS852407_04202	ERS852407_04201	Conserved hypothetical integral membrane protein TIGR02185.	Transporter.	0.950

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

31

average node degree:

5.64

avg. local clustering coefficient:

0.785

expected number of edges:

10

PPI enrichment p-value:

1.38e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006810

Transport

11 of 296

0.87

0.94

3.41e-07

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0022857

Transmembrane transporter activity

10 of 224

0.95

1.05

8.03e-07

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005886

Plasma membrane

7 of 294

0.68

0.48

0.0090

GO:0016020

Membrane

11 of 638

0.54

0.46

0.00014

GO:0016021

Integral component of membrane

8 of 435

0.57

0.41

0.0090

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3162

Palmitate, and RND efflux pump, membrane fusion protein

9 of 13

2.14

6.11

1.80e-15

CL:3160

Mixed, incl. Outer membrane efflux protein, and RND efflux pump, membrane fusion protein

10 of 22

1.96

5.53

4.22e-16

CL:3164

Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains, and RND efflux pump, membrane fusion protein, barrel-sandwich domain

5 of 7

2.16

3.48

5.43e-08

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map01501

beta-Lactam resistance

5 of 46

1.34

1.3

0.00025

map01503

Cationic antimicrobial peptide (CAMP) resistance

4 of 37

1.34

1.09

0.0017

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1990281

Efflux pump complex

5 of 5

2.3

3.6

6.24e-08

GOCC:0098567

Periplasmic side of plasma membrane

5 of 8

2.1

3.22

1.58e-07

GOCC:0005886

Plasma membrane

10 of 277

0.86

0.91

6.69e-07

GOCC:0016020

Membrane

11 of 418

0.72

0.71

6.69e-07

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0175

Coiled coil

6 of 177

0.83

0.6

0.0061

KW-0812

Transmembrane

9 of 415

0.64

0.49

0.0023

KW-1133

Transmembrane helix

8 of 397

0.61

0.44

0.0061

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13533

Biotin-lipoyl like

4 of 5

2.21

2.47

1.36e-05

PF13437

HlyD family secretion protein

3 of 4

2.18

1.71

0.00052

PF03176

MMPL family

3 of 5

2.08

1.67

0.00056

PF16576

Barrel-sandwich domain of CusB or HlyD membrane-fusion

2 of 2

2.3

1.06

0.0111

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR027463

Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains

4 of 4

2.3

2.43

2.01e-05

IPR006143

RND efflux pump, membrane fusion protein

4 of 4

2.3

2.43

2.01e-05

IPR001036

Acriflavin resistance protein

4 of 5

2.21

2.39

2.01e-05

IPR032317

RND efflux pump, membrane fusion protein, barrel-sandwich domain

3 of 3

2.3

1.8

0.00040

IPR039562

Membrane fusion protein, biotin-lipoyl like domain

2 of 3

2.13

0.76

0.0393

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