AIS09992.1 protein (Lactobacillus sp. wkB8) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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gene co-occurrence

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protein homology

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[Homology]

Score

AIS09992.1

PTS system, cellobiose-specific IIA component. (112 aa)

Predicted Functional Partners:

AIS09989.1

0.998

AIS09990.1

0.994

AIS09338.1

0.974

AIS08806.1

0.973

AIS09339.1

0.963

AIS09614.1

0.957

AIS08902.1

0.956

AIS08872.1

0.942

AIS09755.1

0.930

AIS08807.1

0.927

Your Current Organism:

Lactobacillus sp. wkB8

NCBI taxonomy Id: 1545702
Other names: L. sp. wkB8

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIS08806.1	AIS08807.1	LACWKB8_0530	LACWKB8_0531	PTS system, cellobiose-specific IIB component.	PTS system, cellobiose-specific IIA component.	0.997
AIS08806.1	AIS08872.1	LACWKB8_0530	LACWKB8_0597	PTS system, cellobiose-specific IIB component.	Phosphoenolpyruvate-dependent sugar phosphotransferase system EIIC, probable cellobiose specific.	0.972
AIS08806.1	AIS08902.1	LACWKB8_0530	LACWKB8_0628	PTS system, cellobiose-specific IIB component.	Phosphocarrier protein of PTS system.	0.908
AIS08806.1	AIS09338.1	LACWKB8_0530	LACWKB8_1068	PTS system, cellobiose-specific IIB component.	PTS system, cellobiose-specific IIB component.	0.914
AIS08806.1	AIS09339.1	LACWKB8_0530	LACWKB8_1069	PTS system, cellobiose-specific IIB component.	PTS system, cellobiose-specific IIC component.	0.973
AIS08806.1	AIS09614.1	LACWKB8_0530	LACWKB8_1356	PTS system, cellobiose-specific IIB component.	PTS system, cellobiose-specific IIC component.	0.971
AIS08806.1	AIS09755.1	LACWKB8_0530	LACWKB8_1499	PTS system, cellobiose-specific IIB component.	PTS system, cellobiose-specific IIC component.	0.971
AIS08806.1	AIS09989.1	LACWKB8_0530	LACWKB8_1735	PTS system, cellobiose-specific IIB component.	PTS system, diacetylchitobiose-specific IIB component.	0.969
AIS08806.1	AIS09990.1	LACWKB8_0530	LACWKB8_1736	PTS system, cellobiose-specific IIB component.	PTS system, cellobiose-specific IIC component.	0.972
AIS08806.1	AIS09992.1	LACWKB8_0530	LACWKB8_1738	PTS system, cellobiose-specific IIB component.	PTS system, cellobiose-specific IIA component.	0.973
AIS08807.1	AIS08806.1	LACWKB8_0531	LACWKB8_0530	PTS system, cellobiose-specific IIA component.	PTS system, cellobiose-specific IIB component.	0.997
AIS08807.1	AIS08872.1	LACWKB8_0531	LACWKB8_0597	PTS system, cellobiose-specific IIA component.	Phosphoenolpyruvate-dependent sugar phosphotransferase system EIIC, probable cellobiose specific.	0.978
AIS08807.1	AIS08902.1	LACWKB8_0531	LACWKB8_0628	PTS system, cellobiose-specific IIA component.	Phosphocarrier protein of PTS system.	0.956
AIS08807.1	AIS09338.1	LACWKB8_0531	LACWKB8_1068	PTS system, cellobiose-specific IIA component.	PTS system, cellobiose-specific IIB component.	0.991
AIS08807.1	AIS09339.1	LACWKB8_0531	LACWKB8_1069	PTS system, cellobiose-specific IIA component.	PTS system, cellobiose-specific IIC component.	0.979
AIS08807.1	AIS09614.1	LACWKB8_0531	LACWKB8_1356	PTS system, cellobiose-specific IIA component.	PTS system, cellobiose-specific IIC component.	0.977
AIS08807.1	AIS09755.1	LACWKB8_0531	LACWKB8_1499	PTS system, cellobiose-specific IIA component.	PTS system, cellobiose-specific IIC component.	0.977
AIS08807.1	AIS09989.1	LACWKB8_0531	LACWKB8_1735	PTS system, cellobiose-specific IIA component.	PTS system, diacetylchitobiose-specific IIB component.	0.988
AIS08807.1	AIS09990.1	LACWKB8_0531	LACWKB8_1736	PTS system, cellobiose-specific IIA component.	PTS system, cellobiose-specific IIC component.	0.978
AIS08807.1	AIS09992.1	LACWKB8_0531	LACWKB8_1738	PTS system, cellobiose-specific IIA component.	PTS system, cellobiose-specific IIA component.	0.927

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Network Stats

number of nodes:

11

number of edges:

34

average node degree:

6.18

avg. local clustering coefficient:

0.887

expected number of edges:

12

PPI enrichment p-value:

3.43e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006418

tRNA aminoacylation for protein translation

5 of 25

1.76

2.12

1.45e-05

GO:0006399

tRNA metabolic process

6 of 62

1.45

1.73

1.45e-05

GO:0034660

ncRNA metabolic process

7 of 88

1.36

1.67

6.24e-06

GO:0009070

Serine family amino acid biosynthetic process

3 of 10

1.94

1.61

0.00059

GO:0006520

Cellular amino acid metabolic process

7 of 141

1.16

1.27

2.03e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004812

aminoacyl-tRNA ligase activity

5 of 24

1.78

2.32

4.40e-06

GO:0140101

Catalytic activity, acting on a tRNA

6 of 48

1.56

2.01

4.40e-06

GO:0140098

Catalytic activity, acting on RNA

7 of 92

1.34

1.66

4.40e-06

GO:0062105

RNA 2-O-methyltransferase activity

2 of 4

2.16

1.04

0.0115

GO:0003723

RNA binding

4 of 100

1.06

0.65

0.0178

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005829

Cytosol

7 of 364

0.75

0.54

0.0054

GO:0005737

Cytoplasm

10 of 938

0.49

0.37

0.0054

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:386

Aminoacyl-tRNA biosynthesis, and GMP biosynthetic process

4 of 24

1.68

1.39

0.0010

CL:388

Aminoacyl-tRNA synthetase

3 of 12

1.86

1.18

0.0046

CL:392

Aminoacyl-tRNA synthetase, class Ia, anticodon-binding, and Histidine phosphatase superfamily

2 of 5

2.06

0.88

0.0222

CL:888

Cysteine metabolic process, and S-adenosylmethionine metabolic process

2 of 6

1.99

0.87

0.0227

CL:156

Translation, and Transcription, DNA-templated

5 of 139

1.02

0.65

0.0145

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00970

Aminoacyl-tRNA biosynthesis

5 of 30

1.68

2.15

6.06e-06

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005829

Cytosol

8 of 443

0.72

0.57

0.0014

GOCC:0005737

Cytoplasm

11 of 752

0.63

0.56

3.48e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0030

Aminoacyl-tRNA synthetase

5 of 23

1.8

2.38

3.25e-06

KW-0648

Protein biosynthesis

5 of 47

1.49

1.71

2.76e-05

KW-0963

Cytoplasm

8 of 226

1.01

1.07

1.03e-05

KW-0489

Methyltransferase

3 of 67

1.11

0.57

0.0431

KW-0862

Zinc

3 of 68

1.11

0.56

0.0431

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF09334

tRNA synthetases class I (M)

3 of 5

2.24

1.66

0.00071

PF00588

SpoU rRNA Methylase family

2 of 3

2.29

0.89

0.0227

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR009080

Aminoacyl-tRNA synthetase, class Ia, anticodon-binding

3 of 6

2.16

1.35

0.0028

IPR014729

Rossmann-like alpha/beta/alpha sandwich fold

4 of 31

1.57

1.16

0.0028

IPR001537

tRNA/rRNA methyltransferase, SpoU type

2 of 3

2.29

0.76

0.0396

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