Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
CSCA_0398RNA polymerase, sigma-24 subunit, ECF subfamily; Belongs to the sigma-70 factor family. ECF subfamily. (158 aa)    
Predicted Functional Partners:
CSCA_0397
Hypothetical protein.
 
 
 0.960
CSCA_0010
Transcriptional regulator, LuxR family; Belongs to the sigma-70 factor family. ECF subfamily.
  
     0.656
CSCA_2073
RNA polymerase, sigma-24 subunit, ECF subfamily; Belongs to the sigma-70 factor family. ECF subfamily.
  
     0.611
CSCA_2734
RNA polymerase, sigma-24 subunit, ECF subfamily; Belongs to the sigma-70 factor family. ECF subfamily.
  
     0.578
CSCA_0824
Putative RNA polymerase factor sigma C; Belongs to the sigma-70 factor family. ECF subfamily.
  
     0.571
topB
DNA topoisomerase III; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA su [...]
 
 
 
 0.554
CSCA_2002
Hypothetical protein.
  
 
 0.512
CSCA_2399
RNA polymerase sigma factor, sigma-70 family protein; Belongs to the sigma-70 factor family. ECF subfamily.
  
     0.505
CSCA_2462
Putative transmembrane anti-sigma factor.
  
 
 0.502
CSCA_0849
Hypothetical protein; Belongs to the sigma-70 factor family. ECF subfamily.
  
     0.501
Your Current Organism:
Clostridium scatologenes
NCBI taxonomy Id: 1548
Other names: ATCC 25775, Bacillus scatologenes, C. scatologenes, CCUG 9283, Clostridium scatol, DSM 757, NCIB 8855, NCIB:8855, NCTC 12992
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