Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
CSCA_2455Peptidase S8 and S53 subtilisin kexin sedolisin; Belongs to the peptidase S8 family. (422 aa)    
Predicted Functional Partners:
dinB
ImpB/MucB/SamB family protein; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.
  
 
 0.670
CSCA_0502
Diguanylate cyclase (GGDEF) domain protein.
  
 
 0.652
secY
Preprotein translocase, SecY subunit; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.
   
 
 0.599
CSCA_3126
ATPase, P-type (transporting), HAD superfamily, subfamily IC.
   
 
 0.591
CSCA_3550
E1-E2 ATPase-associated domain protein.
   
 
 0.591
CSCA_4179
Peptidase families S8 and S53.
 
 
0.576
CSCA_2768
Cell division FtsK/SpoIIIE.
  
 
 0.545
CSCA_4424
Hypothetical protein.
  
 
 0.545
CSCA_1304
TPR repeat-containing protein.
 
 
 0.538
CSCA_2835
Kinase domain protein.
   
 
 0.536
Your Current Organism:
Clostridium scatologenes
NCBI taxonomy Id: 1548
Other names: ATCC 25775, Bacillus scatologenes, C. scatologenes, CCUG 9283, Clostridium scatol, DSM 757, NCIB 8855, NCIB:8855, NCTC 12992
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