| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CSCA_3204 | CSCA_3213 | CSCA_3204 | CSCA_3213 | CheC, inhibitor of MCP methylation. | HAD-superfamily subfamily IB hydrolase, TIGR01490. | 0.706 |
| CSCA_3212 | CSCA_3213 | CSCA_3212 | CSCA_3213 | Aminotransferase class IV. | HAD-superfamily subfamily IB hydrolase, TIGR01490. | 0.691 |
| CSCA_3212 | hisI | CSCA_3212 | CSCA_2901 | Aminotransferase class IV. | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.645 |
| CSCA_3213 | CSCA_3204 | CSCA_3213 | CSCA_3204 | HAD-superfamily subfamily IB hydrolase, TIGR01490. | CheC, inhibitor of MCP methylation. | 0.706 |
| CSCA_3213 | CSCA_3212 | CSCA_3213 | CSCA_3212 | HAD-superfamily subfamily IB hydrolase, TIGR01490. | Aminotransferase class IV. | 0.691 |
| CSCA_3213 | CSCA_4561 | CSCA_3213 | CSCA_4561 | HAD-superfamily subfamily IB hydrolase, TIGR01490. | Endodeoxyribonuclease RusA. | 0.624 |
| CSCA_3213 | hisA | CSCA_3213 | CSCA_2904 | HAD-superfamily subfamily IB hydrolase, TIGR01490. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.667 |
| CSCA_3213 | hisB | CSCA_3213 | CSCA_2906 | HAD-superfamily subfamily IB hydrolase, TIGR01490. | Imidazoleglycerol-phosphate dehydratase. | 0.692 |
| CSCA_3213 | hisD | CSCA_3213 | CSCA_2907 | HAD-superfamily subfamily IB hydrolase, TIGR01490. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.676 |
| CSCA_3213 | hisF | CSCA_3213 | CSCA_2902 | HAD-superfamily subfamily IB hydrolase, TIGR01490. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.754 |
| CSCA_3213 | hisH | CSCA_3213 | CSCA_2905 | HAD-superfamily subfamily IB hydrolase, TIGR01490. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.683 |
| CSCA_3213 | hisI | CSCA_3213 | CSCA_2901 | HAD-superfamily subfamily IB hydrolase, TIGR01490. | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.930 |
| CSCA_3213 | hisZ | CSCA_3213 | CSCA_2909 | HAD-superfamily subfamily IB hydrolase, TIGR01490. | histidyl-tRNA synthetase 2; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.631 |
| CSCA_4561 | CSCA_3213 | CSCA_4561 | CSCA_3213 | Endodeoxyribonuclease RusA. | HAD-superfamily subfamily IB hydrolase, TIGR01490. | 0.624 |
| hisA | CSCA_3213 | CSCA_2904 | CSCA_3213 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | HAD-superfamily subfamily IB hydrolase, TIGR01490. | 0.667 |
| hisA | hisB | CSCA_2904 | CSCA_2906 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazoleglycerol-phosphate dehydratase. | 0.997 |
| hisA | hisD | CSCA_2904 | CSCA_2907 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.997 |
| hisA | hisF | CSCA_2904 | CSCA_2902 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.998 |
| hisA | hisH | CSCA_2904 | CSCA_2905 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
| hisA | hisI | CSCA_2904 | CSCA_2901 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.999 |