STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LIP_2418Acetolactate synthase; Belongs to the TPP enzyme family. (576 aa)    
Predicted Functional Partners:
LIP_1254
Acetolactate synthase.
 0.998
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
 
 0.988
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
 0.942
LIP_1308
Tartrate dehydrogenase.
 
 0.933
LIP_0017
Pyruvate synthase.
  
 
 0.926
LIP_1253
Acetolactate synthase.
  
  
 
0.924
LIP_0016
Ferredoxin.
    
 0.909
LIP_3023
Malic enzyme.
  
 
 0.908
LIP_0391
Hypothetical protein.
     
  0.900
LIP_2360
Dimethylmenaquinone methyltransferase.
     
  0.900
Your Current Organism:
Limnochorda pilosa
NCBI taxonomy Id: 1555112
Other names: DSM 28787, L. pilosa, Limnochorda pilosa Watanabe et al. 2015, NBRC 110152, bacterium HC45, strain HC45
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