node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
JP36_01440 | mltG | JP36_01440 | JP36_08025 | E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide. | Aminodeoxychorismate lyase; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. | 0.595 |
JP36_01440 | thyA | JP36_01440 | JP36_06215 | E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.612 |
JP36_05345 | folP | JP36_05345 | JP36_08695 | Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.989 |
JP36_05345 | mltG | JP36_05345 | JP36_08025 | Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Aminodeoxychorismate lyase; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. | 0.596 |
JP36_05345 | thyA | JP36_05345 | JP36_06215 | Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.688 |
JP36_08005 | JP36_08010 | JP36_08005 | JP36_08010 | Hypothetical protein. | DNAse. | 0.655 |
JP36_08005 | JP36_08015 | JP36_08005 | JP36_08015 | Hypothetical protein. | DNA polymerase III subunit delta'. | 0.631 |
JP36_08005 | mltG | JP36_08005 | JP36_08025 | Hypothetical protein. | Aminodeoxychorismate lyase; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. | 0.631 |
JP36_08005 | tmk | JP36_08005 | JP36_08020 | Hypothetical protein. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.631 |
JP36_08010 | JP36_08005 | JP36_08010 | JP36_08005 | DNAse. | Hypothetical protein. | 0.655 |
JP36_08010 | JP36_08015 | JP36_08010 | JP36_08015 | DNAse. | DNA polymerase III subunit delta'. | 0.848 |
JP36_08010 | mltG | JP36_08010 | JP36_08025 | DNAse. | Aminodeoxychorismate lyase; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. | 0.933 |
JP36_08010 | tmk | JP36_08010 | JP36_08020 | DNAse. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.801 |
JP36_08015 | JP36_08005 | JP36_08015 | JP36_08005 | DNA polymerase III subunit delta'. | Hypothetical protein. | 0.631 |
JP36_08015 | JP36_08010 | JP36_08015 | JP36_08010 | DNA polymerase III subunit delta'. | DNAse. | 0.848 |
JP36_08015 | mltG | JP36_08015 | JP36_08025 | DNA polymerase III subunit delta'. | Aminodeoxychorismate lyase; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. | 0.843 |
JP36_08015 | tmk | JP36_08015 | JP36_08020 | DNA polymerase III subunit delta'. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.938 |
folP | JP36_05345 | JP36_08695 | JP36_05345 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | 0.989 |
folP | mltG | JP36_08695 | JP36_08025 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Aminodeoxychorismate lyase; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. | 0.648 |
folP | thyA | JP36_08695 | JP36_06215 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.650 |