STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
A0A4P9X9P42-(3-amino-3-carboxypropyl)histidine synthase subunit 2; Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2; Belongs to the DPH1/DPH2 family. DPH2 subfamily. (520 aa)    
Predicted Functional Partners:
A0A4P9X8Q2
2-(3-amino-3-carboxypropyl)histidine synthase subunit 1; Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.
   
0.999
CXG81DRAFT_231
DPH-type MB domain-containing protein.
   
 0.996
A0A4P9X3M5
Uncharacterized protein.
   
 0.918
A0A4P9X723
Tr-type G domain-containing protein.
    
 0.908
A0A4P9X1D7
Diphthine synthase.
   
 0.884
A0A4P9X426
Tr-type G domain-containing protein.
    
 0.808
MEF1
Elongation factor G, mitochondrial; Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
    
 0.808
A0A4P9XFC7
Tr-type G domain-containing protein.
    
 0.808
A0A4P9WYH2
Uncharacterized protein; Belongs to the DEAD box helicase family.
   
   0.730
A0A4P9X6E9
WD_REPEATS_REGION domain-containing protein.
   
    0.678
Your Current Organism:
Caulochytrium protostelioides
NCBI taxonomy Id: 1555241
Other names: C. protostelioides
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.