STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
hxpBPutative phosphatase (YniC); Sugar-phosphate phosphohydrolase that catalyzes the dephosphorylation of D-mannitol 1-phosphate and D-sorbitol 6-phosphate. Also catalyzes the dephosphorylation of 2-deoxyglucose 6-phosphate (2dGlu6P); this is a biologically important activity in vivo since it contributes to the elimination of this toxic compound and plays an important role in the resistance of E.coli to 2-deoxyglucose. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. (222 aa)    
Predicted Functional Partners:
yfbT
Putative phosphatase; Residues 1 to 216 of 216 are 98.61 pct identical to residues 7 to 222 of 222 from Escherichia coli K-12 Strain MG1655: B2293.
  
  
 0.970
mtlD
Mannitol-1-phosphate dehydrogenase; Residues 1 to 382 of 382 are 98.42 pct identical to residues 1 to 382 of 382 from Escherichia coli K-12 Strain MG1655: B3600; Belongs to the mannitol dehydrogenase family.
    
 0.958
mtlA
PTS system, mannitol-specific enzyme IIABC components; Residues 1 to 637 of 637 are 99.37 pct identical to residues 1 to 637 of 637 from Escherichia coli K-12 Strain MG1655: B3599.
  
 
  0.905
cmtA
PTS system, mannitol-specific enzyme II component, cryptic; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II CmtAB PTS system is involved in D-mannitol transport.
   
 
  0.900
cmtB
PTS system, mannitol-specific enzyme II component, cryptic; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II CmtAB PTS system is involved in D-mannitol transport.
     
  0.900
yieH
Putative phosphatase; Residues 1 to 220 of 221 are 85.00 pct identical to residues 1 to 220 of 221 from Escherichia coli K-12 Strain MG1655: B3715.
  
     0.643
ybiV
Orf, hypothetical protein; Residues 1 to 271 of 271 are 98.89 pct identical to residues 1 to 271 of 271 from Escherichia coli K-12 Strain MG1655: B0822.
  
  
 0.621
ydiS
Flavoprotein; Part of an electron transfer system. Belongs to the ETF-QO/FixC family.
      
 0.601
yniB
Orf, hypothetical protein; Residues 1 to 178 of 178 are 97.75 pct identical to residues 1 to 178 of 178 from Escherichia coli K-12 Strain MG1655: B1726.
 
     0.597
ycjT
Orf, hypothetical protein; Residues 1 to 755 of 755 are 98.14 pct identical to residues 1 to 755 of 755 from Escherichia coli K-12 Strain MG1655: B1316.
 
  
 0.533
Your Current Organism:
Escherichia coli O157H7 EDL933
NCBI taxonomy Id: 155864
Other names: E. coli O157:H7 str. EDL933, Escherichia coli O157:H7 EDL933, Escherichia coli O157:H7 str. EDL933, Escherichia coli O157:H7 strain EDL933
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