node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
guaA | hisA | Z3771 | Z3186 | GMP synthetase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase; Residues 1 to 246 of 246 are 98.37 pct identical to residues 1 to 246 of 246 from Escherichia coli K-12 Strain MG1655: B2024; Belongs to the HisA/HisF family. | 0.741 |
guaA | hisB | Z3771 | Z3184 | GMP synthetase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Imidazoleglycerolphosphate dehydratase and histidinol-phosphate phosphatase; Residues 1 to 356 of 356 are 99.43 pct identical to residues 1 to 356 of 356 from Escherichia coli K-12 Strain MG1655: B2022; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | 0.406 |
guaA | hisF | Z3771 | Z3187 | GMP synthetase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | 0.470 |
guaA | hisH | Z3771 | Z3185 | GMP synthetase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity). | 0.562 |
guaA | pheA | Z3771 | Z3891 | GMP synthetase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Chorismate mutase-P and prephenate dehydratase; Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate. | 0.672 |
guaA | trpC | Z3771 | Z2549 | GMP synthetase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | N-(5-phosphoribosyl)anthranilate isomerase and indole-3-glycerolphosphate synthetase; Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the TrpF domain; the second reaction is catalyzed by the synthase, coded by the TrpC domain (By similarity). | 0.723 |
hisA | guaA | Z3186 | Z3771 | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase; Residues 1 to 246 of 246 are 98.37 pct identical to residues 1 to 246 of 246 from Escherichia coli K-12 Strain MG1655: B2024; Belongs to the HisA/HisF family. | GMP synthetase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.741 |
hisA | hisB | Z3186 | Z3184 | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase; Residues 1 to 246 of 246 are 98.37 pct identical to residues 1 to 246 of 246 from Escherichia coli K-12 Strain MG1655: B2024; Belongs to the HisA/HisF family. | Imidazoleglycerolphosphate dehydratase and histidinol-phosphate phosphatase; Residues 1 to 356 of 356 are 99.43 pct identical to residues 1 to 356 of 356 from Escherichia coli K-12 Strain MG1655: B2022; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | 0.999 |
hisA | hisC | Z3186 | Z3183 | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase; Residues 1 to 246 of 246 are 98.37 pct identical to residues 1 to 246 of 246 from Escherichia coli K-12 Strain MG1655: B2024; Belongs to the HisA/HisF family. | Histidinol-phosphate aminotransferase; Residues 1 to 356 of 356 are 99.43 pct identical to residues 1 to 356 of 356 from Escherichia coli K-12 Strain MG1655: B2021; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.997 |
hisA | hisD | Z3186 | Z3182 | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase; Residues 1 to 246 of 246 are 98.37 pct identical to residues 1 to 246 of 246 from Escherichia coli K-12 Strain MG1655: B2024; Belongs to the HisA/HisF family. | L-histidinal:NAD+ oxidoreductase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.997 |
hisA | hisF | Z3186 | Z3187 | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase; Residues 1 to 246 of 246 are 98.37 pct identical to residues 1 to 246 of 246 from Escherichia coli K-12 Strain MG1655: B2024; Belongs to the HisA/HisF family. | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | 0.999 |
hisA | hisG | Z3186 | Z3181 | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase; Residues 1 to 246 of 246 are 98.37 pct identical to residues 1 to 246 of 246 from Escherichia coli K-12 Strain MG1655: B2024; Belongs to the HisA/HisF family. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | 0.998 |
hisA | hisH | Z3186 | Z3185 | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase; Residues 1 to 246 of 246 are 98.37 pct identical to residues 1 to 246 of 246 from Escherichia coli K-12 Strain MG1655: B2024; Belongs to the HisA/HisF family. | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity). | 0.999 |
hisA | hisI | Z3186 | Z3188 | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase; Residues 1 to 246 of 246 are 98.37 pct identical to residues 1 to 246 of 246 from Escherichia coli K-12 Strain MG1655: B2024; Belongs to the HisA/HisF family. | Phosphoribosyl-amp cyclohydrolase; Residues 1 to 203 of 203 are 98.52 pct identical to residues 1 to 203 of 203 from Escherichia coli K-12 Strain MG1655: B2026; In the C-terminal section; belongs to the PRA-PH family. | 0.999 |
hisA | pheA | Z3186 | Z3891 | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase; Residues 1 to 246 of 246 are 98.37 pct identical to residues 1 to 246 of 246 from Escherichia coli K-12 Strain MG1655: B2024; Belongs to the HisA/HisF family. | Chorismate mutase-P and prephenate dehydratase; Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate. | 0.640 |
hisA | trpC | Z3186 | Z2549 | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase; Residues 1 to 246 of 246 are 98.37 pct identical to residues 1 to 246 of 246 from Escherichia coli K-12 Strain MG1655: B2024; Belongs to the HisA/HisF family. | N-(5-phosphoribosyl)anthranilate isomerase and indole-3-glycerolphosphate synthetase; Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the TrpF domain; the second reaction is catalyzed by the synthase, coded by the TrpC domain (By similarity). | 0.823 |
hisB | guaA | Z3184 | Z3771 | Imidazoleglycerolphosphate dehydratase and histidinol-phosphate phosphatase; Residues 1 to 356 of 356 are 99.43 pct identical to residues 1 to 356 of 356 from Escherichia coli K-12 Strain MG1655: B2022; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | GMP synthetase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.406 |
hisB | hisA | Z3184 | Z3186 | Imidazoleglycerolphosphate dehydratase and histidinol-phosphate phosphatase; Residues 1 to 356 of 356 are 99.43 pct identical to residues 1 to 356 of 356 from Escherichia coli K-12 Strain MG1655: B2022; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase; Residues 1 to 246 of 246 are 98.37 pct identical to residues 1 to 246 of 246 from Escherichia coli K-12 Strain MG1655: B2024; Belongs to the HisA/HisF family. | 0.999 |
hisB | hisC | Z3184 | Z3183 | Imidazoleglycerolphosphate dehydratase and histidinol-phosphate phosphatase; Residues 1 to 356 of 356 are 99.43 pct identical to residues 1 to 356 of 356 from Escherichia coli K-12 Strain MG1655: B2022; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | Histidinol-phosphate aminotransferase; Residues 1 to 356 of 356 are 99.43 pct identical to residues 1 to 356 of 356 from Escherichia coli K-12 Strain MG1655: B2021; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.999 |
hisB | hisD | Z3184 | Z3182 | Imidazoleglycerolphosphate dehydratase and histidinol-phosphate phosphatase; Residues 1 to 356 of 356 are 99.43 pct identical to residues 1 to 356 of 356 from Escherichia coli K-12 Strain MG1655: B2022; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | L-histidinal:NAD+ oxidoreductase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.999 |