node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
chpR | ppx | Z4098 | Z3765 | Suppressor of inhibitory function of ChpA, PemI-like, autoregulated; Antitoxin component of a type II toxin-antitoxin (TA) system. Labile antitoxin that binds to its cognate MazF endoribonuclease toxin and neutralizes its activity. Both MazE and MazE-MazF bind to the promoter region of the mazE-mazF operon to inhibit their transcription. Belongs to the PemI family. | Exopolyphosphatase; Degradation of inorganic polyphosphates (polyP). Releases orthophosphate processively from the ends of the polyP chain. | 0.461 |
chpR | relA | Z4098 | Z4099 | Suppressor of inhibitory function of ChpA, PemI-like, autoregulated; Antitoxin component of a type II toxin-antitoxin (TA) system. Labile antitoxin that binds to its cognate MazF endoribonuclease toxin and neutralizes its activity. Both MazE and MazE-MazF bind to the promoter region of the mazE-mazF operon to inhibit their transcription. Belongs to the PemI family. | (p)ppGpp synthetase I (GTP pyrophosphokinase); In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp (By similarity). | 0.765 |
chpR | symE | Z4098 | Z5945 | Suppressor of inhibitory function of ChpA, PemI-like, autoregulated; Antitoxin component of a type II toxin-antitoxin (TA) system. Labile antitoxin that binds to its cognate MazF endoribonuclease toxin and neutralizes its activity. Both MazE and MazE-MazF bind to the promoter region of the mazE-mazF operon to inhibit their transcription. Belongs to the PemI family. | Orf; Involved in the degradation and recycling of damaged RNA. It is itself a target for degradation by the ATP-dependent protease Lon. Belongs to the SymE family. | 0.700 |
dsbC | ppx | Z4231 | Z3765 | Protein disulfide isomerase II; Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbC is reoxidized by a yet uncharacterized protein. Also acts as a disulfide isomerase (By similarity). | Exopolyphosphatase; Degradation of inorganic polyphosphates (polyP). Releases orthophosphate processively from the ends of the polyP chain. | 0.441 |
gppA | ppk | Z5289 | Z3764 | Guanosine pentaphosphatase; Catalyzes the conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the 'stringent response', an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities. | Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP); Belongs to the polyphosphate kinase 1 (PPK1) family. | 0.935 |
gppA | ppx | Z5289 | Z3765 | Guanosine pentaphosphatase; Catalyzes the conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the 'stringent response', an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities. | Exopolyphosphatase; Degradation of inorganic polyphosphates (polyP). Releases orthophosphate processively from the ends of the polyP chain. | 0.921 |
gppA | relA | Z5289 | Z4099 | Guanosine pentaphosphatase; Catalyzes the conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the 'stringent response', an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities. | (p)ppGpp synthetase I (GTP pyrophosphokinase); In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp (By similarity). | 0.974 |
gppA | spoT | Z5289 | Z5076 | Guanosine pentaphosphatase; Catalyzes the conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the 'stringent response', an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities. | (p)ppGpp synthetase II; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the degradation of ppGpp into GDP. It may also be capable of catalyzing the synthesis of ppGpp (By similarity); Belongs to the RelA/SpoT family. | 0.912 |
ppk | gppA | Z3764 | Z5289 | Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP); Belongs to the polyphosphate kinase 1 (PPK1) family. | Guanosine pentaphosphatase; Catalyzes the conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the 'stringent response', an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities. | 0.935 |
ppk | ppx | Z3764 | Z3765 | Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP); Belongs to the polyphosphate kinase 1 (PPK1) family. | Exopolyphosphatase; Degradation of inorganic polyphosphates (polyP). Releases orthophosphate processively from the ends of the polyP chain. | 0.989 |
ppk | purM | Z3764 | Z3762 | Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP); Belongs to the polyphosphate kinase 1 (PPK1) family. | Phosphoribosylaminoimidazole synthetase = AIR synthetase; Residues 1 to 345 of 345 are 99.13 pct identical to residues 1 to 345 of 345 from Escherichia coli K-12 Strain MG1655: B2499; Belongs to the AIR synthase family. | 0.534 |
ppk | purN | Z3764 | Z3763 | Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP); Belongs to the polyphosphate kinase 1 (PPK1) family. | Phosphoribosylglycinamide formyltransferase 1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.506 |
ppx | chpR | Z3765 | Z4098 | Exopolyphosphatase; Degradation of inorganic polyphosphates (polyP). Releases orthophosphate processively from the ends of the polyP chain. | Suppressor of inhibitory function of ChpA, PemI-like, autoregulated; Antitoxin component of a type II toxin-antitoxin (TA) system. Labile antitoxin that binds to its cognate MazF endoribonuclease toxin and neutralizes its activity. Both MazE and MazE-MazF bind to the promoter region of the mazE-mazF operon to inhibit their transcription. Belongs to the PemI family. | 0.461 |
ppx | dsbC | Z3765 | Z4231 | Exopolyphosphatase; Degradation of inorganic polyphosphates (polyP). Releases orthophosphate processively from the ends of the polyP chain. | Protein disulfide isomerase II; Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbC is reoxidized by a yet uncharacterized protein. Also acts as a disulfide isomerase (By similarity). | 0.441 |
ppx | gppA | Z3765 | Z5289 | Exopolyphosphatase; Degradation of inorganic polyphosphates (polyP). Releases orthophosphate processively from the ends of the polyP chain. | Guanosine pentaphosphatase; Catalyzes the conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the 'stringent response', an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities. | 0.921 |
ppx | ppk | Z3765 | Z3764 | Exopolyphosphatase; Degradation of inorganic polyphosphates (polyP). Releases orthophosphate processively from the ends of the polyP chain. | Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP); Belongs to the polyphosphate kinase 1 (PPK1) family. | 0.989 |
ppx | purM | Z3765 | Z3762 | Exopolyphosphatase; Degradation of inorganic polyphosphates (polyP). Releases orthophosphate processively from the ends of the polyP chain. | Phosphoribosylaminoimidazole synthetase = AIR synthetase; Residues 1 to 345 of 345 are 99.13 pct identical to residues 1 to 345 of 345 from Escherichia coli K-12 Strain MG1655: B2499; Belongs to the AIR synthase family. | 0.497 |
ppx | purN | Z3765 | Z3763 | Exopolyphosphatase; Degradation of inorganic polyphosphates (polyP). Releases orthophosphate processively from the ends of the polyP chain. | Phosphoribosylglycinamide formyltransferase 1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.497 |
ppx | relA | Z3765 | Z4099 | Exopolyphosphatase; Degradation of inorganic polyphosphates (polyP). Releases orthophosphate processively from the ends of the polyP chain. | (p)ppGpp synthetase I (GTP pyrophosphokinase); In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp (By similarity). | 0.929 |
ppx | spoT | Z3765 | Z5076 | Exopolyphosphatase; Degradation of inorganic polyphosphates (polyP). Releases orthophosphate processively from the ends of the polyP chain. | (p)ppGpp synthetase II; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the degradation of ppGpp into GDP. It may also be capable of catalyzing the synthesis of ppGpp (By similarity); Belongs to the RelA/SpoT family. | 0.912 |