STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
gcvPGlycine decarboxylase, P protein of glycine cleavage system; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (957 aa)    
Predicted Functional Partners:
gcvH
In glycine cleavage complex, carrier of aminomethyl moiety via covalently bound lipoyl cofactor; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
 
 0.999
gcvT
Aminomethyltransferase (T protein; The glycine cleavage system catalyzes the degradation of glycine.
 0.999
Z1548
Putative aminomethyltransferase; Residues 4 to 347 of 386 are 26.14 pct identical to residues 7 to 370 of 398 from GenPept 118 : gi|5458520|emb|CAB50008.1| (AJ248286) PROBABLE AMINOMETHYLTRANSFERASE (EC 2.1.2.10) (GLYCINE CLEAVAGE SYSTEM T PROTEIN) [Pyrococcus abyssi]; Belongs to the GcvT family.
 0.996
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.996
gltB
Glutamate synthase, large subunit; Residues 1 to 1517 of 1517 are 99.53 pct identical to residues 1 to 1517 of 1517 from Escherichia coli K-12 Strain MG1655: B3212.
   
 0.989
lpdA
Lipoamide dehydrogenase (NADH); Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
 
 
 0.988
ybjU
Putative arylsulfatase; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. L-threo-phenylserine and L-erythro- phenylserine are also good substrates (By similarity).
    
 0.956
kbl
2-amino-3-ketobutyrate CoA ligase (glycine acetyltransferase); Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.
  
 
 0.947
purD
Phosphoribosylglycinamide synthetase = GAR synthetase; Residues 1 to 429 of 429 are 97.90 pct identical to residues 1 to 429 of 429 from Escherichia coli K-12 Strain MG1655: B4005; Belongs to the GARS family.
  
  
 0.944
fumA-2
Putative fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
   
    0.918
Your Current Organism:
Escherichia coli O157H7 EDL933
NCBI taxonomy Id: 155864
Other names: E. coli O157:H7 str. EDL933, Escherichia coli O157:H7 EDL933, Escherichia coli O157:H7 str. EDL933, Escherichia coli O157:H7 strain EDL933
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