node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Z1548 | gcvH | Z1548 | Z4241 | Putative aminomethyltransferase; Residues 4 to 347 of 386 are 26.14 pct identical to residues 7 to 370 of 398 from GenPept 118 : gi|5458520|emb|CAB50008.1| (AJ248286) PROBABLE AMINOMETHYLTRANSFERASE (EC 2.1.2.10) (GLYCINE CLEAVAGE SYSTEM T PROTEIN) [Pyrococcus abyssi]; Belongs to the GcvT family. | In glycine cleavage complex, carrier of aminomethyl moiety via covalently bound lipoyl cofactor; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.999 |
Z1548 | gcvP | Z1548 | Z4240 | Putative aminomethyltransferase; Residues 4 to 347 of 386 are 26.14 pct identical to residues 7 to 370 of 398 from GenPept 118 : gi|5458520|emb|CAB50008.1| (AJ248286) PROBABLE AMINOMETHYLTRANSFERASE (EC 2.1.2.10) (GLYCINE CLEAVAGE SYSTEM T PROTEIN) [Pyrococcus abyssi]; Belongs to the GcvT family. | Glycine decarboxylase, P protein of glycine cleavage system; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.996 |
Z1548 | gltB | Z1548 | Z4576 | Putative aminomethyltransferase; Residues 4 to 347 of 386 are 26.14 pct identical to residues 7 to 370 of 398 from GenPept 118 : gi|5458520|emb|CAB50008.1| (AJ248286) PROBABLE AMINOMETHYLTRANSFERASE (EC 2.1.2.10) (GLYCINE CLEAVAGE SYSTEM T PROTEIN) [Pyrococcus abyssi]; Belongs to the GcvT family. | Glutamate synthase, large subunit; Residues 1 to 1517 of 1517 are 99.53 pct identical to residues 1 to 1517 of 1517 from Escherichia coli K-12 Strain MG1655: B3212. | 0.479 |
Z1548 | glyA | Z1548 | Z3827 | Putative aminomethyltransferase; Residues 4 to 347 of 386 are 26.14 pct identical to residues 7 to 370 of 398 from GenPept 118 : gi|5458520|emb|CAB50008.1| (AJ248286) PROBABLE AMINOMETHYLTRANSFERASE (EC 2.1.2.10) (GLYCINE CLEAVAGE SYSTEM T PROTEIN) [Pyrococcus abyssi]; Belongs to the GcvT family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.671 |
Z1548 | lpdA | Z1548 | Z0126 | Putative aminomethyltransferase; Residues 4 to 347 of 386 are 26.14 pct identical to residues 7 to 370 of 398 from GenPept 118 : gi|5458520|emb|CAB50008.1| (AJ248286) PROBABLE AMINOMETHYLTRANSFERASE (EC 2.1.2.10) (GLYCINE CLEAVAGE SYSTEM T PROTEIN) [Pyrococcus abyssi]; Belongs to the GcvT family. | Lipoamide dehydrogenase (NADH); Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. | 0.841 |
fumA-2 | gcvP | Z0887 | Z4240 | Putative fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Glycine decarboxylase, P protein of glycine cleavage system; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.918 |
gcvH | Z1548 | Z4241 | Z1548 | In glycine cleavage complex, carrier of aminomethyl moiety via covalently bound lipoyl cofactor; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Putative aminomethyltransferase; Residues 4 to 347 of 386 are 26.14 pct identical to residues 7 to 370 of 398 from GenPept 118 : gi|5458520|emb|CAB50008.1| (AJ248286) PROBABLE AMINOMETHYLTRANSFERASE (EC 2.1.2.10) (GLYCINE CLEAVAGE SYSTEM T PROTEIN) [Pyrococcus abyssi]; Belongs to the GcvT family. | 0.999 |
gcvH | gcvP | Z4241 | Z4240 | In glycine cleavage complex, carrier of aminomethyl moiety via covalently bound lipoyl cofactor; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glycine decarboxylase, P protein of glycine cleavage system; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.999 |
gcvH | gcvT | Z4241 | Z4242 | In glycine cleavage complex, carrier of aminomethyl moiety via covalently bound lipoyl cofactor; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Aminomethyltransferase (T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.999 |
gcvH | gltB | Z4241 | Z4576 | In glycine cleavage complex, carrier of aminomethyl moiety via covalently bound lipoyl cofactor; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glutamate synthase, large subunit; Residues 1 to 1517 of 1517 are 99.53 pct identical to residues 1 to 1517 of 1517 from Escherichia coli K-12 Strain MG1655: B3212. | 0.931 |
gcvH | glyA | Z4241 | Z3827 | In glycine cleavage complex, carrier of aminomethyl moiety via covalently bound lipoyl cofactor; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.965 |
gcvH | kbl | Z4241 | Z5044 | In glycine cleavage complex, carrier of aminomethyl moiety via covalently bound lipoyl cofactor; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 2-amino-3-ketobutyrate CoA ligase (glycine acetyltransferase); Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | 0.457 |
gcvH | lpdA | Z4241 | Z0126 | In glycine cleavage complex, carrier of aminomethyl moiety via covalently bound lipoyl cofactor; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Lipoamide dehydrogenase (NADH); Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. | 0.975 |
gcvP | Z1548 | Z4240 | Z1548 | Glycine decarboxylase, P protein of glycine cleavage system; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Putative aminomethyltransferase; Residues 4 to 347 of 386 are 26.14 pct identical to residues 7 to 370 of 398 from GenPept 118 : gi|5458520|emb|CAB50008.1| (AJ248286) PROBABLE AMINOMETHYLTRANSFERASE (EC 2.1.2.10) (GLYCINE CLEAVAGE SYSTEM T PROTEIN) [Pyrococcus abyssi]; Belongs to the GcvT family. | 0.996 |
gcvP | fumA-2 | Z4240 | Z0887 | Glycine decarboxylase, P protein of glycine cleavage system; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Putative fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | 0.918 |
gcvP | gcvH | Z4240 | Z4241 | Glycine decarboxylase, P protein of glycine cleavage system; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | In glycine cleavage complex, carrier of aminomethyl moiety via covalently bound lipoyl cofactor; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.999 |
gcvP | gcvT | Z4240 | Z4242 | Glycine decarboxylase, P protein of glycine cleavage system; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Aminomethyltransferase (T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.999 |
gcvP | gltB | Z4240 | Z4576 | Glycine decarboxylase, P protein of glycine cleavage system; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Glutamate synthase, large subunit; Residues 1 to 1517 of 1517 are 99.53 pct identical to residues 1 to 1517 of 1517 from Escherichia coli K-12 Strain MG1655: B3212. | 0.989 |
gcvP | glyA | Z4240 | Z3827 | Glycine decarboxylase, P protein of glycine cleavage system; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.996 |
gcvP | kbl | Z4240 | Z5044 | Glycine decarboxylase, P protein of glycine cleavage system; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 2-amino-3-ketobutyrate CoA ligase (glycine acetyltransferase); Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | 0.947 |