STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
eaeIntimin adherence protein; Necessary for the production of attaching and effacing lesions on tissue culture cells; Belongs to the intimin/invasin family. (934 aa)    
Predicted Functional Partners:
tir
Putative translocated intimin receptor protein; Multifunctional protein that is required for efficient pedestal formation in host epithelial cells during infection. The extracellular region acts as a receptor for bacterial intimin, allowing the bacterium to attach tightly to the host-cell surface. Simultaneously, the intracellular region initiates a signaling cascade in the host cell, which leads to actin polymerization and formation of actin pedestals at the sites of bacterial adhesion. In strain EDL933, acts via the effector protein EspF(U), in a phosphotyrosine- and NCK- independent [...]
   
 0.999
iha
Putative receptor; Residues 1 to 696 of 696 are 99.85 pct identical to residues 1 to 696 of 696 from GenPept 118 : gi|7108480|gb|AAF36432.1|AF126104_1 (AF126104) adhesin [Escherichia coli O157:H7].
    
 
 0.770
fliC
Flagellar biosynthesis; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
    
 
 0.752
cesT
Hypothetical protein; Chaperone for the type III secretion of Tir. Probably stabilizes the protein, prevents inappropriate protein- proteininteractions and aids in secretion (By similarity). Belongs to the CesT/SycH chaperone family.
     
 0.741
per
Perosamine synthetase; Catalyzes the synthesis of GDP-perosamine from GDP-4-keto-6- deoxy-D-mannose and L-glutamate. Can use only L-glutamate as amino donor; Belongs to the DegT/DnrJ/EryC1 family.
   
  
 0.723
espP
Hypothetical protein; Serine protease capable of cleaving pepsin A and human coagulation factor V, which may contribute to the mucosal hemorrhage observed in hemorrhagic colitis.
      
 0.721
stx1B
Shiga-like toxin 1 subunit B encoded within prophage CP-933V; Residues 1 to 89 of 89 are 100.00 pct identical to residues 1 to 89 of 89 from GenPept 118 : gi|2668770|gb|AAD04657.1| (AF034975) Shiga-like toxin B subunit [Bacteriophage H-19B].
      
 0.721
espB
Secreted protein EspB; Residues 1 to 312 of 312 are 99.67 pct identical to residues 1 to 312 of 312 from GenPept 118 : gi|3115186|emb|CAA73508.1| (Y13068) EspB protein [Escherichia coli].
      
 0.721
espD
Secreted protein EspD; Residues 1 to 374 of 374 are 100.00 pct identical to residues 1 to 374 of 374 from GenPept 118 : gi|3414889|gb|AAC31500.1| (AF071034) L0021 [Escherichia coli].
      
 0.721
espA
Secreted protein EspA; Residues 1 to 192 of 192 are 100.00 pct identical to residues 1 to 192 of 192 from GenPept 118 : gi|3414890|gb|AAC31501.1| (AF071034) L0022 [Escherichia coli].
      
 0.721
Your Current Organism:
Escherichia coli O157H7 EDL933
NCBI taxonomy Id: 155864
Other names: E. coli O157:H7 str. EDL933, Escherichia coli O157:H7 EDL933, Escherichia coli O157:H7 str. EDL933, Escherichia coli O157:H7 strain EDL933
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