STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
glnAGlutamine synthetase; Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia; Belongs to the glutamine synthetase family. (469 aa)    
Predicted Functional Partners:
glnL
Histidine protein kinase sensor for GlnG regulator (nitrogen regulator II, NRII); Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Under conditions of nitrogen limitation, NtrB autophosphorylates and transfers the phosphoryl group to NtrC. In the presence of nitrogen, acts as a phosphatase that dephosphorylates and inactivates NtrC.
  
  
 0.993
gltB
Glutamate synthase, large subunit; Residues 1 to 1517 of 1517 are 99.53 pct identical to residues 1 to 1517 of 1517 from Escherichia coli K-12 Strain MG1655: B3212.
  
 
 0.990
gdhA
NADP-specific glutamate dehydrogenase; Residues 1 to 447 of 447 are 99.32 pct identical to residues 1 to 447 of 447 from Escherichia coli K-12 Strain MG1655: B1761; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
  
 
 0.979
gltD
Glutamate synthase, small subunit; Residues 1 to 472 of 472 are 99.36 pct identical to residues 1 to 472 of 472 from Escherichia coli K-12 Strain MG1655: B3213.
  
 
 0.957
putA
Proline dehydrogenase, P5C dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; Belongs to the aldehyde dehydrogenase family. In the N-terminal section; belongs to the proline dehydrogenase family.
   
 
 0.956
carA
Carbamoyl-phosphate synthetase, glutamine (small) subunit; Residues 1 to 382 of 382 are 100.00 pct identical to residues 1 to 382 of 382 from Escherichia coli K-12 Strain MG1655: B0032; Belongs to the CarA family.
 
 
 0.936
carB
Carbamoyl-phosphate synthase large subunit; Residues 1 to 1073 of 1073 are 99.72 pct identical to residues 1 to 1073 of 1073 from Escherichia coli K-12 Strain MG1655: B0033.
 
 
 0.929
purF
Amidophosphoribosyltransferase = PRPP amidotransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
 
  
 0.925
glmS
L-glutamine:D-fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
  
 
 0.925
nirB
Nitrite reductase (NAD(P)H) subunit; Residues 1 to 847 of 847 are 99.76 pct identical to residues 1 to 847 of 847 from Escherichia coli K-12 Strain MG1655: B3365; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
    
 0.920
Your Current Organism:
Escherichia coli O157H7 EDL933
NCBI taxonomy Id: 155864
Other names: E. coli O157:H7 str. EDL933, Escherichia coli O157:H7 EDL933, Escherichia coli O157:H7 str. EDL933, Escherichia coli O157:H7 strain EDL933
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