STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
purDPhosphoribosylglycinamide synthetase = GAR synthetase; Residues 1 to 429 of 429 are 97.90 pct identical to residues 1 to 429 of 429 from Escherichia coli K-12 Strain MG1655: B4005; Belongs to the GARS family. (429 aa)    
Predicted Functional Partners:
purE
Phosphoribosylaminoimidazole carboxylase = AIR carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).
  
 0.999
purF
Amidophosphoribosyltransferase = PRPP amidotransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
 0.999
purM
Phosphoribosylaminoimidazole synthetase = AIR synthetase; Residues 1 to 345 of 345 are 99.13 pct identical to residues 1 to 345 of 345 from Escherichia coli K-12 Strain MG1655: B2499; Belongs to the AIR synthase family.
  
 0.999
purN
Phosphoribosylglycinamide formyltransferase 1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
 
 0.999
purH
Phosphoribosylaminoimidazolecarboxamide formyltransferase = AICAR formyltransferase; Residues 1 to 529 of 529 are 99.62 pct identical to residues 1 to 529 of 529 from Escherichia coli K-12 Strain MG1655: B4006.
 
 
 0.998
purL
Phosphoribosylformyl-glycineamide synthetase = FGAM synthetase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.
  
 0.995
purK
Phosphoribosylaminoimidazole carboxylase = AIR carboxylase, CO(2)-fixing subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
 
  
 0.988
purT
Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family.
 
 
 0.978
purC
Phosphoribosylaminoimidazole-succinocarboxamide synthetase = SAICAR synthetase; Residues 1 to 237 of 237 are 100.00 pct identical to residues 1 to 237 of 237 from Escherichia coli K-12 Strain MG1655: B2476.
 
 
 0.963
guaA
GMP synthetase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
 
  
 0.958
Your Current Organism:
Escherichia coli O157H7 EDL933
NCBI taxonomy Id: 155864
Other names: E. coli O157:H7 str. EDL933, Escherichia coli O157:H7 EDL933, Escherichia coli O157:H7 str. EDL933, Escherichia coli O157:H7 strain EDL933
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