Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| gcvT | glyA | Z4242 | Z3827 | Aminomethyltransferase (T protein; The glycine cleavage system catalyzes the degradation of glycine. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.996 |
| gcvT | metF | Z4242 | Z5496 | Aminomethyltransferase (T protein; The glycine cleavage system catalyzes the degradation of glycine. | 5,10-methylenetetrahydrofolate reductase; Residues 1 to 296 of 296 are 99.66 pct identical to residues 1 to 296 of 296 from Escherichia coli K-12 Strain MG1655: B3941; Belongs to the methylenetetrahydrofolate reductase family. | 0.920 |
| gcvT | metH | Z4242 | Z5610 | Aminomethyltransferase (T protein; The glycine cleavage system catalyzes the degradation of glycine. | B12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase, repressor of metE and metF; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.957 |
| glyA | gcvT | Z3827 | Z4242 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Aminomethyltransferase (T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.996 |
| glyA | metE | Z3827 | Z5351 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Tetrahydropteroyltriglutamate methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.484 |
| glyA | metF | Z3827 | Z5496 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 5,10-methylenetetrahydrofolate reductase; Residues 1 to 296 of 296 are 99.66 pct identical to residues 1 to 296 of 296 from Escherichia coli K-12 Strain MG1655: B3941; Belongs to the methylenetetrahydrofolate reductase family. | 0.965 |
| glyA | metH | Z3827 | Z5610 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | B12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase, repressor of metE and metF; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.961 |
| glyA | metK | Z3827 | Z4287 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Methionine adenosyltransferase 1 (AdoMet synthetase); Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.656 |
| glyA | metL | Z3827 | Z5495 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Aspartokinase II and homoserine dehydrogenase II; Residues 1 to 810 of 810 are 99.87 pct identical to residues 1 to 810 of 810 from Escherichia coli K-12 Strain MG1655: B3940; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.536 |
| glyA | thrA | Z3827 | Z0002 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Aspartokinase I, homoserine dehydrogenase I; Residues 1 to 820 of 820 are 99.75 pct identical to residues 1 to 820 of 820 from Escherichia coli K-12 Strain MG1655: B0002; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.536 |
| metB | metC | Z5494 | Z4361 | Cystathionine gamma-synthase; Residues 1 to 386 of 386 are 99.48 pct identical to residues 1 to 386 of 386 from Escherichia coli K-12 Strain MG1655: B3939. | Cystathionine beta-lyase (beta-cystathionase); Residues 1 to 395 of 395 are 98.48 pct identical to residues 1 to 395 of 395 from Escherichia coli K-12 Strain MG1655: B3008. | 0.961 |
| metB | metE | Z5494 | Z5351 | Cystathionine gamma-synthase; Residues 1 to 386 of 386 are 99.48 pct identical to residues 1 to 386 of 386 from Escherichia coli K-12 Strain MG1655: B3939. | Tetrahydropteroyltriglutamate methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.976 |
| metB | metF | Z5494 | Z5496 | Cystathionine gamma-synthase; Residues 1 to 386 of 386 are 99.48 pct identical to residues 1 to 386 of 386 from Escherichia coli K-12 Strain MG1655: B3939. | 5,10-methylenetetrahydrofolate reductase; Residues 1 to 296 of 296 are 99.66 pct identical to residues 1 to 296 of 296 from Escherichia coli K-12 Strain MG1655: B3941; Belongs to the methylenetetrahydrofolate reductase family. | 0.998 |
| metB | metH | Z5494 | Z5610 | Cystathionine gamma-synthase; Residues 1 to 386 of 386 are 99.48 pct identical to residues 1 to 386 of 386 from Escherichia coli K-12 Strain MG1655: B3939. | B12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase, repressor of metE and metF; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.979 |
| metB | metK | Z5494 | Z4287 | Cystathionine gamma-synthase; Residues 1 to 386 of 386 are 99.48 pct identical to residues 1 to 386 of 386 from Escherichia coli K-12 Strain MG1655: B3939. | Methionine adenosyltransferase 1 (AdoMet synthetase); Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.673 |
| metB | metL | Z5494 | Z5495 | Cystathionine gamma-synthase; Residues 1 to 386 of 386 are 99.48 pct identical to residues 1 to 386 of 386 from Escherichia coli K-12 Strain MG1655: B3939. | Aspartokinase II and homoserine dehydrogenase II; Residues 1 to 810 of 810 are 99.87 pct identical to residues 1 to 810 of 810 from Escherichia coli K-12 Strain MG1655: B3940; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.996 |
| metB | thrA | Z5494 | Z0002 | Cystathionine gamma-synthase; Residues 1 to 386 of 386 are 99.48 pct identical to residues 1 to 386 of 386 from Escherichia coli K-12 Strain MG1655: B3939. | Aspartokinase I, homoserine dehydrogenase I; Residues 1 to 820 of 820 are 99.75 pct identical to residues 1 to 820 of 820 from Escherichia coli K-12 Strain MG1655: B0002; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.946 |
| metB | ygaG | Z5494 | Z3988 | Cystathionine gamma-synthase; Residues 1 to 386 of 386 are 99.48 pct identical to residues 1 to 386 of 386 from Escherichia coli K-12 Strain MG1655: B3939. | Orf, hypothetical protein; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. | 0.941 |
| metC | metB | Z4361 | Z5494 | Cystathionine beta-lyase (beta-cystathionase); Residues 1 to 395 of 395 are 98.48 pct identical to residues 1 to 395 of 395 from Escherichia coli K-12 Strain MG1655: B3008. | Cystathionine gamma-synthase; Residues 1 to 386 of 386 are 99.48 pct identical to residues 1 to 386 of 386 from Escherichia coli K-12 Strain MG1655: B3939. | 0.961 |
| metC | metE | Z4361 | Z5351 | Cystathionine beta-lyase (beta-cystathionase); Residues 1 to 395 of 395 are 98.48 pct identical to residues 1 to 395 of 395 from Escherichia coli K-12 Strain MG1655: B3008. | Tetrahydropteroyltriglutamate methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.971 |
page 1 of 5