Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
NPD11_148Formiminotransferase-cyclodeaminase family protein; [E] COG3404 Methenyl tetrahydrofolate cyclohydrolase. (214 aa)    
Predicted Functional Partners:
fhs
Formate--tetrahydrofolate ligase family protein; [F] COG2759 Formyltetrahydrofolate synthetase; Belongs to the formate--tetrahydrofolate ligase family.
 
  
 0.967
folD
Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
    
 0.957
AQM60312.1
MTHFS_bact: 5-formyltetrahydrofolate cyclo-ligase; [H] COG0212 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.
    
  0.910
purH
purH: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; [F] COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful).
    
 0.904
purN
Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
     
  0.900
noxC
Nitroreductase family protein; [C] COG0778 Nitroreductase.
 
    0.714
AQM59946.1
Aminotransferase class-V family protein; [E] COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase.
 
  
 0.552
NPD11_146
Tetratricopeptide repeat family protein; [R] COG0457 FOG: TPR repeat.
       0.551
AQM59735.1
Pterin binding enzyme family protein; [E] COG1410 Methionine synthase I, cobalamin-binding domain.
  
  
 0.507
lpdA
lipoamide_DH: dihydrolipoyl dehydrogenase; [C] COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes.
     
 0.489
Your Current Organism:
Clostridium baratii
NCBI taxonomy Id: 1561
Other names: ATCC 27638, Acuformis perennis, BCRC 14541, C. baratii, CCRC 14541, CCRC:14541, CCUG 24033, CIP 104306, Clostridium barati, Clostridium paraperfringens, Clostridium perenne, DSM 601, Inflabilis barati
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