| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AQM60146.1 | dnaK | NPD11_1072 | NPD11_2933 | birA_ligase: biotin--[acetyl-CoA-carboxylase] ligase; [H] COG0340 Biotin-(acetyl-CoA carboxylase) ligase. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.446 |
| AQM60146.1 | groS | NPD11_1072 | NPD11_1519 | birA_ligase: biotin--[acetyl-CoA-carboxylase] ligase; [H] COG0340 Biotin-(acetyl-CoA carboxylase) ligase. | 10 kDa chaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.747 |
| AQM60146.1 | guaA | NPD11_1072 | NPD11_1505 | birA_ligase: biotin--[acetyl-CoA-carboxylase] ligase; [H] COG0340 Biotin-(acetyl-CoA carboxylase) ligase. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.773 |
| AQM60385.1 | clpP | NPD11_1681 | NPD11_1126 | istB-like ATP binding family protein; [O] COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.926 |
| AQM60385.1 | dnaJ | NPD11_1681 | NPD11_2934 | istB-like ATP binding family protein; [O] COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.791 |
| AQM60385.1 | dnaK | NPD11_1681 | NPD11_2933 | istB-like ATP binding family protein; [O] COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.972 |
| AQM60385.1 | groL | NPD11_1681 | NPD11_1518 | istB-like ATP binding family protein; [O] COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.753 |
| AQM60385.1 | groS | NPD11_1681 | NPD11_1519 | istB-like ATP binding family protein; [O] COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | 10 kDa chaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.740 |
| AQM60385.1 | grpE | NPD11_1681 | NPD11_2932 | istB-like ATP binding family protein; [O] COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | grpE family protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depe [...] | 0.842 |
| AQM60385.1 | guaA | NPD11_1681 | NPD11_1505 | istB-like ATP binding family protein; [O] COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.417 |
| AQM60385.1 | htpG | NPD11_1681 | NPD11_2281 | istB-like ATP binding family protein; [O] COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | Hsp90 family protein; Molecular chaperone. Has ATPase activity. | 0.798 |
| clpB | clpP | NPD11_1208 | NPD11_1126 | ATP-dependent chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.903 |
| clpB | dnaJ | NPD11_1208 | NPD11_2934 | ATP-dependent chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.778 |
| clpB | dnaK | NPD11_1208 | NPD11_2933 | ATP-dependent chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.973 |
| clpB | groL | NPD11_1208 | NPD11_1518 | ATP-dependent chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.814 |
| clpB | groS | NPD11_1208 | NPD11_1519 | ATP-dependent chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 10 kDa chaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.791 |
| clpB | grpE | NPD11_1208 | NPD11_2932 | ATP-dependent chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | grpE family protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depe [...] | 0.883 |
| clpB | guaA | NPD11_1208 | NPD11_1505 | ATP-dependent chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.417 |
| clpB | htpG | NPD11_1208 | NPD11_2281 | ATP-dependent chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Hsp90 family protein; Molecular chaperone. Has ATPase activity. | 0.830 |
| clpP | AQM60385.1 | NPD11_1126 | NPD11_1681 | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | istB-like ATP binding family protein; [O] COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | 0.926 |
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