STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
disAHelix-hairpin-helix motif family protein; Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis. (354 aa)    
Predicted Functional Partners:
radA
DNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
  
  
 0.956
nagB
Glucosamine-6-phosphate deaminase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
       0.614
AQM58766.1
UTRA domain protein; [K] COG2188 Transcriptional regulators.
       0.614
stp
[T] COG0631 Serine/threonine protein phosphatase.
      
 0.522
AQM59033.1
PIN domain protein; [R] COG4956 Integral membrane protein (PIN domain superfamily).
  
  
 0.477
AQM60526.1
Firmicute transcriptional repressor of class III stress gene family protein; [K] COG4463 Transcriptional repressor of class III stress genes; Belongs to the CtsR family.
  
  
 0.461
AQM61179.1
Hypothetical protein; ATP:guanido phosphotransferase, C-terminal catalytic domain protein; [E] COG3869 Arginine kinase.
  
    0.440
AQM58669.1
uvrB/uvrC motif family protein; [S] COG3880 Uncharacterized protein with conserved CXXC pairs.
  
    0.437
NPD11_162
Conserved hypothetical protein; [S] COG3879 Uncharacterized protein conserved in bacteria.
  
     0.415
AQM60385.1
istB-like ATP binding family protein; [O] COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family.
  
  
 0.413
Your Current Organism:
Clostridium baratii
NCBI taxonomy Id: 1561
Other names: ATCC 27638, Acuformis perennis, BCRC 14541, C. baratii, CCRC 14541, CCRC:14541, CCUG 24033, CIP 104306, Clostridium barati, Clostridium paraperfringens, Clostridium perenne, DSM 601, Inflabilis barati
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