| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| gpr | spo0A | NPD11_2925 | NPD11_354 | GPR endopeptidase; Initiates the rapid degradation of small, acid-soluble proteins during spore germination; Belongs to the peptidase A25 family. | Sporulation transcription factor Spo0A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. | 0.838 |
| gpr | spoIIAB | NPD11_2925 | NPD11_2916 | GPR endopeptidase; Initiates the rapid degradation of small, acid-soluble proteins during spore germination; Belongs to the peptidase A25 family. | Anti-sigma F factor; Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition. | 0.830 |
| gpr | spoIID | NPD11_2925 | NPD11_1384 | GPR endopeptidase; Initiates the rapid degradation of small, acid-soluble proteins during spore germination; Belongs to the peptidase A25 family. | spore_II_D: stage II sporulation protein D; [D] COG2385 Sporulation protein and related proteins. | 0.499 |
| gpr | spoIIIAA | NPD11_2925 | NPD11_374 | GPR endopeptidase; Initiates the rapid degradation of small, acid-soluble proteins during spore germination; Belongs to the peptidase A25 family. | spore_III_AA: stage III sporulation protein AA; [S] COG3854 Uncharacterized protein conserved in bacteria. | 0.753 |
| gpr | spoIIIAD | NPD11_2925 | NPD11_371 | GPR endopeptidase; Initiates the rapid degradation of small, acid-soluble proteins during spore germination; Belongs to the peptidase A25 family. | spore_III_AD: stage III sporulation protein AD. | 0.770 |
| gpr | spoIIIAG | NPD11_2925 | NPD11_368 | GPR endopeptidase; Initiates the rapid degradation of small, acid-soluble proteins during spore germination; Belongs to the peptidase A25 family. | spore_III_AG: stage III sporulation protein AG. | 0.767 |
| gpr | spoIIID | NPD11_2925 | NPD11_1382 | GPR endopeptidase; Initiates the rapid degradation of small, acid-soluble proteins during spore germination; Belongs to the peptidase A25 family. | spore_III_D: sporulation transcriptional regulator SpoIIID. | 0.771 |
| gpr | spoIIP | NPD11_2925 | NPD11_2926 | GPR endopeptidase; Initiates the rapid degradation of small, acid-soluble proteins during spore germination; Belongs to the peptidase A25 family. | spore_II_P: stage II sporulation P family protein. | 0.913 |
| gpr | spoIIR | NPD11_2925 | NPD11_1413 | GPR endopeptidase; Initiates the rapid degradation of small, acid-soluble proteins during spore germination; Belongs to the peptidase A25 family. | spore_II_R: stage II sporulation protein R. | 0.770 |
| gpr | spoIVA | NPD11_2925 | NPD11_172 | GPR endopeptidase; Initiates the rapid degradation of small, acid-soluble proteins during spore germination; Belongs to the peptidase A25 family. | Stage IV sporulation protein A; ATPase. Has a role at an early stage in the morphogenesis of the spore coat. | 0.833 |
| spo0A | gpr | NPD11_354 | NPD11_2925 | Sporulation transcription factor Spo0A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. | GPR endopeptidase; Initiates the rapid degradation of small, acid-soluble proteins during spore germination; Belongs to the peptidase A25 family. | 0.838 |
| spo0A | spoIIAB | NPD11_354 | NPD11_2916 | Sporulation transcription factor Spo0A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. | Anti-sigma F factor; Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition. | 0.899 |
| spo0A | spoIID | NPD11_354 | NPD11_1384 | Sporulation transcription factor Spo0A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. | spore_II_D: stage II sporulation protein D; [D] COG2385 Sporulation protein and related proteins. | 0.563 |
| spo0A | spoIIIAA | NPD11_354 | NPD11_374 | Sporulation transcription factor Spo0A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. | spore_III_AA: stage III sporulation protein AA; [S] COG3854 Uncharacterized protein conserved in bacteria. | 0.849 |
| spo0A | spoIIIAD | NPD11_354 | NPD11_371 | Sporulation transcription factor Spo0A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. | spore_III_AD: stage III sporulation protein AD. | 0.850 |
| spo0A | spoIIIAG | NPD11_354 | NPD11_368 | Sporulation transcription factor Spo0A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. | spore_III_AG: stage III sporulation protein AG. | 0.815 |
| spo0A | spoIIID | NPD11_354 | NPD11_1382 | Sporulation transcription factor Spo0A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. | spore_III_D: sporulation transcriptional regulator SpoIIID. | 0.887 |
| spo0A | spoIIP | NPD11_354 | NPD11_2926 | Sporulation transcription factor Spo0A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. | spore_II_P: stage II sporulation P family protein. | 0.820 |
| spo0A | spoIIR | NPD11_354 | NPD11_1413 | Sporulation transcription factor Spo0A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. | spore_II_R: stage II sporulation protein R. | 0.848 |
| spo0A | spoIVA | NPD11_354 | NPD11_172 | Sporulation transcription factor Spo0A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. | Stage IV sporulation protein A; ATPase. Has a role at an early stage in the morphogenesis of the spore coat. | 0.860 |