STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
purAAdenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (428 aa)    
Predicted Functional Partners:
purB
purB: adenylosuccinate lyase; [F] COG0015 Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
 
 0.995
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
 
 
 0.993
NPD11_911
FGAM-synthase: phosphoribosylformylglycinamidine synthase; [F] COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain.
  
  
 0.985
purH
purH: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; [F] COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful).
  
 0.979
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
 
  
 0.954
argG
argG: argininosuccinate synthase; [E] COG0137 Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily.
  
 
 0.928
pyrB
Asp_carb_tr: aspartate carbamoyltransferase; [F] COG0540 Aspartate carbamoyltransferase, catalytic chain; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
  
 
 0.925
hpt
HGPRTase: hypoxanthine phosphoribosyltransferase; [F] COG0634 Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
  
 
 0.923
hpt-2
HGPRTase: hypoxanthine phosphoribosyltransferase; [F] COG0634 Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
  
 
 0.923
aspD
Asp_4_decarbox: aspartate 4-decarboxylase; [E] COG0436 Aspartate/tyrosine/aromatic aminotransferase.
  
 0.912
Your Current Organism:
Clostridium baratii
NCBI taxonomy Id: 1561
Other names: ATCC 27638, Acuformis perennis, BCRC 14541, C. baratii, CCRC 14541, CCRC:14541, CCUG 24033, CIP 104306, Clostridium barati, Clostridium paraperfringens, Clostridium perenne, DSM 601, Inflabilis barati
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