node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AQM60146.1 | hfq | NPD11_1072 | NPD11_302 | birA_ligase: biotin--[acetyl-CoA-carboxylase] ligase; [H] COG0340 Biotin-(acetyl-CoA carboxylase) ligase. | RNA chaperone Hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | 0.526 |
AQM60146.1 | nth | NPD11_1072 | NPD11_2648 | birA_ligase: biotin--[acetyl-CoA-carboxylase] ligase; [H] COG0340 Biotin-(acetyl-CoA carboxylase) ligase. | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | 0.426 |
AQM60146.1 | tadA | NPD11_1072 | NPD11_2048 | birA_ligase: biotin--[acetyl-CoA-carboxylase] ligase; [H] COG0340 Biotin-(acetyl-CoA carboxylase) ligase. | Cytidine and deoxycytidylate deaminase zinc-binding region family protein; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. | 0.952 |
AQM60146.1 | xth | NPD11_1072 | NPD11_287 | birA_ligase: biotin--[acetyl-CoA-carboxylase] ligase; [H] COG0340 Biotin-(acetyl-CoA carboxylase) ligase. | exoDNase_III: exodeoxyribonuclease III; [L] COG0708 Exonuclease III. | 0.795 |
AQM60693.1 | xth | NPD11_1499 | NPD11_287 | Pseudouridine synthase family protein; [J] COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases; Belongs to the pseudouridine synthase RsuA family. | exoDNase_III: exodeoxyribonuclease III; [L] COG0708 Exonuclease III. | 0.653 |
AQM61254.1 | xth | NPD11_2248 | NPD11_287 | Pseudouridine synthase family protein; [J] COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases; Belongs to the pseudouridine synthase RsuA family. | exoDNase_III: exodeoxyribonuclease III; [L] COG0708 Exonuclease III. | 0.653 |
NPD11_70 | polA | NPD11_70 | NPD11_1018 | 3mg: DNA-3-methyladenine glycosylase family protein; [L] COG2094 3-methyladenine DNA glycosylase; Belongs to the DNA glycosylase MPG family. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.435 |
NPD11_70 | xth | NPD11_70 | NPD11_287 | 3mg: DNA-3-methyladenine glycosylase family protein; [L] COG2094 3-methyladenine DNA glycosylase; Belongs to the DNA glycosylase MPG family. | exoDNase_III: exodeoxyribonuclease III; [L] COG0708 Exonuclease III. | 0.696 |
dnaN | polA | NPD11_1907 | NPD11_1018 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.999 |
dnaN | ung | NPD11_1907 | NPD11_2156 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. | 0.611 |
dnaN | xth | NPD11_1907 | NPD11_287 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | exoDNase_III: exodeoxyribonuclease III; [L] COG0708 Exonuclease III. | 0.921 |
hfq | AQM60146.1 | NPD11_302 | NPD11_1072 | RNA chaperone Hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | birA_ligase: biotin--[acetyl-CoA-carboxylase] ligase; [H] COG0340 Biotin-(acetyl-CoA carboxylase) ligase. | 0.526 |
hfq | polA | NPD11_302 | NPD11_1018 | RNA chaperone Hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.589 |
hfq | xth | NPD11_302 | NPD11_287 | RNA chaperone Hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | exoDNase_III: exodeoxyribonuclease III; [L] COG0708 Exonuclease III. | 0.703 |
nth | AQM60146.1 | NPD11_2648 | NPD11_1072 | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | birA_ligase: biotin--[acetyl-CoA-carboxylase] ligase; [H] COG0340 Biotin-(acetyl-CoA carboxylase) ligase. | 0.426 |
nth | polA | NPD11_2648 | NPD11_1018 | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.817 |
nth | ung | NPD11_2648 | NPD11_2156 | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. | 0.652 |
nth | xth | NPD11_2648 | NPD11_287 | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | exoDNase_III: exodeoxyribonuclease III; [L] COG0708 Exonuclease III. | 0.995 |
polA | NPD11_70 | NPD11_1018 | NPD11_70 | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 3mg: DNA-3-methyladenine glycosylase family protein; [L] COG2094 3-methyladenine DNA glycosylase; Belongs to the DNA glycosylase MPG family. | 0.435 |
polA | dnaN | NPD11_1018 | NPD11_1907 | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.999 |