| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| sigF | spo0A | NPD11_2917 | NPD11_354 | spore_sigF: RNA polymerase sigma-F factor; [K] COG1191 DNA-directed RNA polymerase specialized sigma subunit; Belongs to the sigma-70 factor family. | Sporulation transcription factor Spo0A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. | 0.775 |
| sigF | spoIIAA | NPD11_2917 | NPD11_2915 | spore_sigF: RNA polymerase sigma-F factor; [K] COG1191 DNA-directed RNA polymerase specialized sigma subunit; Belongs to the sigma-70 factor family. | spore_II_AA: anti-sigma F factor antagonist; [T] COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor); Belongs to the anti-sigma-factor antagonist family. | 0.965 |
| sigF | spoIIAB | NPD11_2917 | NPD11_2916 | spore_sigF: RNA polymerase sigma-F factor; [K] COG1191 DNA-directed RNA polymerase specialized sigma subunit; Belongs to the sigma-70 factor family. | Anti-sigma F factor; Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition. | 0.989 |
| sigF | spoIIE | NPD11_2917 | NPD11_1718 | spore_sigF: RNA polymerase sigma-F factor; [K] COG1191 DNA-directed RNA polymerase specialized sigma subunit; Belongs to the sigma-70 factor family. | spore_II_E: stage II sporulation protein E; [TK] COG2208 Serine phosphatase RsbU, regulator of sigma subunit. | 0.714 |
| sigF | spoIIP | NPD11_2917 | NPD11_2926 | spore_sigF: RNA polymerase sigma-F factor; [K] COG1191 DNA-directed RNA polymerase specialized sigma subunit; Belongs to the sigma-70 factor family. | spore_II_P: stage II sporulation P family protein. | 0.617 |
| sigF | spoIIR | NPD11_2917 | NPD11_1413 | spore_sigF: RNA polymerase sigma-F factor; [K] COG1191 DNA-directed RNA polymerase specialized sigma subunit; Belongs to the sigma-70 factor family. | spore_II_R: stage II sporulation protein R. | 0.649 |
| sigF | spoIVA | NPD11_2917 | NPD11_172 | spore_sigF: RNA polymerase sigma-F factor; [K] COG1191 DNA-directed RNA polymerase specialized sigma subunit; Belongs to the sigma-70 factor family. | Stage IV sporulation protein A; ATPase. Has a role at an early stage in the morphogenesis of the spore coat. | 0.734 |
| sigF | spoVAC | NPD11_2917 | NPD11_2919 | spore_sigF: RNA polymerase sigma-F factor; [K] COG1191 DNA-directed RNA polymerase specialized sigma subunit; Belongs to the sigma-70 factor family. | spore_V_AC: stage V sporulation protein AC. | 0.864 |
| sigF | spoVAD | NPD11_2917 | NPD11_2920 | spore_sigF: RNA polymerase sigma-F factor; [K] COG1191 DNA-directed RNA polymerase specialized sigma subunit; Belongs to the sigma-70 factor family. | spore_V_AD: stage V sporulation protein AD. | 0.845 |
| sigF | spoVAE | NPD11_2917 | NPD11_2921 | spore_sigF: RNA polymerase sigma-F factor; [K] COG1191 DNA-directed RNA polymerase specialized sigma subunit; Belongs to the sigma-70 factor family. | spore_V_AE: stage V sporulation protein AE. | 0.844 |
| spo0A | sigF | NPD11_354 | NPD11_2917 | Sporulation transcription factor Spo0A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. | spore_sigF: RNA polymerase sigma-F factor; [K] COG1191 DNA-directed RNA polymerase specialized sigma subunit; Belongs to the sigma-70 factor family. | 0.775 |
| spo0A | spoIIAA | NPD11_354 | NPD11_2915 | Sporulation transcription factor Spo0A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. | spore_II_AA: anti-sigma F factor antagonist; [T] COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor); Belongs to the anti-sigma-factor antagonist family. | 0.775 |
| spo0A | spoIIAB | NPD11_354 | NPD11_2916 | Sporulation transcription factor Spo0A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. | Anti-sigma F factor; Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition. | 0.899 |
| spo0A | spoIIE | NPD11_354 | NPD11_1718 | Sporulation transcription factor Spo0A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. | spore_II_E: stage II sporulation protein E; [TK] COG2208 Serine phosphatase RsbU, regulator of sigma subunit. | 0.898 |
| spo0A | spoIIP | NPD11_354 | NPD11_2926 | Sporulation transcription factor Spo0A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. | spore_II_P: stage II sporulation P family protein. | 0.820 |
| spo0A | spoIIR | NPD11_354 | NPD11_1413 | Sporulation transcription factor Spo0A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. | spore_II_R: stage II sporulation protein R. | 0.848 |
| spo0A | spoIVA | NPD11_354 | NPD11_172 | Sporulation transcription factor Spo0A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. | Stage IV sporulation protein A; ATPase. Has a role at an early stage in the morphogenesis of the spore coat. | 0.860 |
| spo0A | spoVAC | NPD11_354 | NPD11_2919 | Sporulation transcription factor Spo0A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. | spore_V_AC: stage V sporulation protein AC. | 0.768 |
| spo0A | spoVAD | NPD11_354 | NPD11_2920 | Sporulation transcription factor Spo0A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. | spore_V_AD: stage V sporulation protein AD. | 0.844 |
| spo0A | spoVAE | NPD11_354 | NPD11_2921 | Sporulation transcription factor Spo0A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. | spore_V_AE: stage V sporulation protein AE. | 0.748 |